Cell type atlas - CD44 - The Human Protein Atlas

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CD44

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	CD44
Gene descriptionⁱ Full gene name according to HGNC.	CD44 molecule (Indian blood group)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Blood group antigen proteins Cancer-related genes CD markers FDA approved drug targets Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	26

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Ductal cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (hTERT-RPE1)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Suprabasal keratinocytes, Basal keratinocytes, Ductal cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	89 NX
Lung	89 NX

Alveolar cells type 2	340 NX
Lung	340 NX

B-cells	169 NX
Colon	332 NX
Kidney	156 NX
Liver	136 NX

Basal glandular cells	264 NX
Prostate	264 NX

Basal keratinocytes	888 NX
Skin	888 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	4 NX
Heart muscle	4 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	19 NX
Lung	19 NX

Club cells	135 NX
Lung	135 NX

Collecting duct cells	19 NX
Kidney	19 NX

Cone photoreceptor cells	2 NX
Eye	2 NX

Cytotrophoblasts	4 NX
Placenta	4 NX

Distal tubular cells	2 NX
Kidney	2 NX

Ductal cells	859 NX
Pancreas	859 NX

Early spermatids	30 NX
Testis	30 NX

Endothelial cells	53 NX
Skin	181 NX
Placenta	109 NX
Pancreas	65 NX
Lung	58 NX
Prostate	53 NX
Eye	35 NX
Heart muscle	9 NX
Liver	7 NX
Testis	4 NX

Enterocytes	5 NX
Colon	7 NX
Rectum	5 NX
Small intestine	5 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	742 NX
Pancreas	742 NX

Extravillous trophoblasts	4 NX
Placenta	4 NX

Fibroblasts	144 NX
Skin	902 NX
Prostate	476 NX
Lung	144 NX
Placenta	82 NX
Heart muscle	49 NX

Glandular cells	293 NX
Prostate	293 NX

Granulocytes	733 NX
Lung	898 NX
Colon	569 NX

Hepatocytes	3 NX
Liver	3 NX

Hofbauer cells	235 NX
Placenta	235 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	96 NX
Rectum	101 NX
Colon	92 NX

Ito cells	20 NX
Liver	20 NX

Kupffer cells	427 NX
Liver	427 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	21 NX
Testis	21 NX

Macrophages	612 NX
Skin	1247 NX
Lung	653 NX
Prostate	607 NX
Pancreas	604 NX
Kidney	434 NX
Testis	294 NX

Melanocytes	574 NX
Skin	574 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	514 NX
Pancreas	514 NX

Mucus-secreting cells	85 NX
Colon	92 NX
Rectum	77 NX
Small intestine	61 NX

Muller glia cells	27 NX
Eye	27 NX

Pancreatic endocrine cells	788 NX
Pancreas	788 NX

Paneth cells	9 NX
Rectum	21 NX
Colon	9 NX
Small intestine	0 NX

Peritubular cells	0 NX
Testis	0 NX

Proximal tubular cells	1 NX
Kidney	1 NX

Rod photoreceptor cells	2 NX
Eye	2 NX

Sertoli cells	155 NX
Testis	155 NX

Smooth muscle cells	254 NX
Skin	545 NX
Prostate	444 NX
Pancreas	225 NX
Heart muscle	35 NX

Spermatocytes	0 NX
Testis	0 NX

Spermatogonia	0 NX
Testis	0 NX

Suprabasal keratinocytes	896 NX
Skin	896 NX

Syncytiotrophoblasts	15 NX
Placenta	15 NX

T-cells	245 NX
Skin	1092 NX
Prostate	632 NX
Colon	345 NX
Kidney	245 NX
Lung	237 NX
Liver	132 NX

Undifferentiated cells	66 NX
Small intestine	115 NX
Colon	58 NX
Rectum	48 NX

Urothelial cells	304 NX
Prostate	304 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.