NR1H3 protein expression summary - The Human Protein Atlas

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NR1H3

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Nuclear receptor subfamily 1 group H member 3
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	NR1H3 (LXR-a, RLD-1)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (adipose tissue)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, Hofbauer cells, Hepatocytes)
Blood specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Immune cell enhanced (intermediate monocyte)
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low human brain regional specificity
Cancer prognostic summary	Prognostic marker in renal cancer (unfavorable), urothelial cancer (favorable), endometrial cancer (favorable) and liver cancer (unfavorable)
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Subcellular summaryⁱ The main location is characterized by presence in all tested cell lines and/or increased intensity compared to other locations. Additional locations are characterized by either a markedly lower staining intensity than the main location, or that it is only observed in a subset of the cell lines.	Located in Nucleoplasm, Cytosol
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity 1, 2. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES (By similarity). LXRES are DR4-type response elements characterized by direct repeats of two similar hexanuclotide half-sites spaced by four nucleotides (By similarity). Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8 3. Interplays functionally with RORA for the regulation of genes involved in liver metabolism (By similarity). Induces LPCAT3-dependent phospholipid remodeling in endoplasmic reticulum (ER) membranes of hepatocytes, driving SREBF1 processing and lipogenesis (By similarity). Via LPCAT3, triggers the incorporation of arachidonate into phosphatidylcholines of ER membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Via LPCAT3 also counteracts lipid-induced ER stress response and inflammation, likely by modulating SRC kinase membrane compartmentalization and limiting the synthesis of lipid inflammatory mediators (By similarity).... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Activator, DNA-binding, Receptor
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Transcription, Transcription regulation
Ligand (UniProt)ⁱ Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.	Metal-binding, Zinc
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	The protein encoded by this gene belongs to the NR1 subfamily of the nuclear receptor superfamily. The NR1 family members are key regulators of macrophage function, controlling transcriptional programs involved in lipid homeostasis and inflammation. This protein is highly expressed in visceral organs, including liver, kidney and intestine. It forms a heterodimer with retinoid X receptor (RXR), and regulates expression of target genes containing retinoid response elements. Studies in mice lacking this gene suggest that it may play an important role in the regulation of cholesterol homeostasis. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011]... show less

TISSUE ATLASⁱ Summary of data presented in the Tissue Atlas and representative images of protein expression (left) and mRNA expression (right). The images are clickable and will redirect to more Tissue Atlas data. The Tissue Atlas contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (adipose tissue)
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	General nuclear expression.

SINGLE CELL TYPE ATLASⁱ Summary of data presented in the Cell Type Atlas and an interactive image showing mRNA expression in cell type groups e.g. epithelial cells and germ cells. The image is clickable and will redirect to more Cell Type Atlas data. The Cell Type Atlas contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Kupffer cells, Hofbauer cells, Hepatocytes)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (ASC TERT1, HSkMC)

PATHOLOGY ATLASⁱ Summary of data presented in the Pathology Atlas , with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology Atlas data. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more
	Renal cancer p<0.001
Prognostic summary	Prognostic marker in renal cancer (unfavorable), urothelial cancer (favorable), endometrial cancer (favorable) and liver cancer (unfavorable)
Cancer specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Low cancer specificity
Cancer distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in all

BRAIN ATLASⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity

BLOOD ATLASⁱ Summary of data presented in the Blood Atlas and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more Blood Atlas data. The Blood Atlas contains single cell type RNA information covering various immune cells in the blood, e.g. B-cells and granulocytes. Analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) and proteins detected in human blood are also presented. Read more

Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (intermediate monocyte)
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No (not applicable)
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	No

CELL ATLASⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Localized to the Nucleoplasm
Additional locationⁱ Additonal subcellular location(s) for the encoded protein(s) in human cells. The additional location(s) may not be present i all cell lines and may have lower staining intensity compared to the main location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	In addition localized to the Cytosol
Cell cycle dependencyⁱ Cell-cycle dependance of single-cell varations in RNA and/or protein expression as observed in an additional assay for characterizing single-cell varations. "NA" indicates a lack of such data. Read more	NA

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	NR1H3 (HGNC Symbol)
Synonyms	LXR-a, RLD-1
Description	Nuclear receptor subfamily 1 group H member 3 (HGNC Symbol)
Chromosome	11
Cytoband	p11.2
Chromosome location (bp)	47248300 - 47269032
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	17
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Nuclear receptors Plasma proteins Transcription factors
Ensembl	ENSG00000025434 (version 92.38)
Entrez gene	10062
UniProt	Q13133 (UniProt - Evidence at protein level)
neXtProt	NX_Q13133
Antibodypedia	NR1H3 antibodies

PROTEIN BROWSERⁱ

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NR1H3-201

NR1H3-202

NR1H3-203

NR1H3-204

NR1H3-205

NR1H3-208

NR1H3-209

NR1H3-210

NR1H3-211

NR1H3-212

NR1H3-213

NR1H3-214

NR1H3-217

NR1H3-221

NR1H3-230

NR1H3-233

NR1H3-235

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PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
NR1H3-201 ENSP00000378793 ENST00000395397	Q13133 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043235 [receptor complex] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:0090575 [RNA polymerase II transcription factor complex] GO:2000188 [regulation of cholesterol homeostasis] Show all	402 aa 45.7 kDa	No	0
NR1H3-202 ENSP00000385073 ENST00000405576	B5MBY7 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	342 aa 38.9 kDa	No	0
NR1H3-203 ENSP00000384745 ENST00000405853	Q13133 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043235 [receptor complex] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:0090575 [RNA polymerase II transcription factor complex] GO:2000188 [regulation of cholesterol homeostasis] Show all	387 aa 43.6 kDa	No	0
NR1H3-204 ENSP00000385801 ENST00000407404	Q13133 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043235 [receptor complex] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:0090575 [RNA polymerase II transcription factor complex] GO:2000188 [regulation of cholesterol homeostasis] Show all	387 aa 43.6 kDa	No	0
NR1H3-205 ENSP00000412636 ENST00000412937	C9J2C8 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	134 aa 14.8 kDa	No	0
NR1H3-208 ENSP00000403696 ENST00000436029	C9JBS2 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	212 aa 23.1 kDa	No	0
NR1H3-209 ENSP00000403798 ENST00000436778	C9JJ16 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	202 aa 22 kDa	No	0
NR1H3-210 ENSP00000396132 ENST00000437276	C9JEC2 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		68 aa 6.9 kDa	No	0
NR1H3-211 ENSP00000387946 ENST00000441012	Q13133 [Direct mapping] Oxysterols receptor LXR-alpha F1D8N1 [Target identity:100%; Query identity:100%] Liver X nuclear receptor alpha variant 1 Show all	Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043235 [receptor complex] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:0090575 [RNA polymerase II transcription factor complex] GO:2000188 [regulation of cholesterol homeostasis] Show all	447 aa 50.4 kDa	No	0
NR1H3-212 ENSP00000391005 ENST00000444396	C9J4R0 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	193 aa 21.1 kDa	No	0
NR1H3-213 ENSP00000415591 ENST00000449369	C9JCS0 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	205 aa 22.4 kDa	No	0
NR1H3-214 ENSP00000413095 ENST00000457932	C9JTS4 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		77 aa 7.8 kDa	No	0
NR1H3-217 ENSP00000420656 ENST00000467728	Q13133 [Direct mapping] Oxysterols receptor LXR-alpha F1D8N1 [Target identity:100%; Query identity:100%] Liver X nuclear receptor alpha variant 1 Show all	Nuclear receptors Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Transcription factors Zinc-coordinating DNA-binding domains Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000790 [nuclear chromatin] GO:0000981 [RNA polymerase II transcription factor activity, sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0003713 [transcription coactivator activity] GO:0004879 [nuclear receptor activity] GO:0005515 [protein binding] GO:0005634 [nucleus] GO:0005654 [nucleoplasm] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006367 [transcription initiation from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010745 [negative regulation of macrophage derived foam cell differentiation] GO:0010867 [positive regulation of triglyceride biosynthetic process] GO:0010870 [positive regulation of receptor biosynthetic process] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0015485 [cholesterol binding] GO:0030522 [intracellular receptor signaling pathway] GO:0032270 [positive regulation of cellular protein metabolic process] GO:0032369 [negative regulation of lipid transport] GO:0032376 [positive regulation of cholesterol transport] GO:0032570 [response to progesterone] GO:0032810 [sterol response element binding] GO:0034145 [positive regulation of toll-like receptor 4 signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0042752 [regulation of circadian rhythm] GO:0043031 [negative regulation of macrophage activation] GO:0043235 [receptor complex] GO:0043277 [apoptotic cell clearance] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0045723 [positive regulation of fatty acid biosynthetic process] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0048550 [negative regulation of pinocytosis] GO:0050728 [negative regulation of inflammatory response] GO:0051006 [positive regulation of lipoprotein lipase activity] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0060336 [negative regulation of interferon-gamma-mediated signaling pathway] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:0090575 [RNA polymerase II transcription factor complex] GO:2000188 [regulation of cholesterol homeostasis] Show all	447 aa 50.4 kDa	No	0
NR1H3-221 ENSP00000433271 ENST00000481889	E9PLL4 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	466 aa 52.8 kDa	No	0
NR1H3-230 ENSP00000432073 ENST00000527949	E9PID2 [Direct mapping] Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0008270 [zinc ion binding] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0046872 [metal ion binding] Show all	296 aa 34.1 kDa	No	0
NR1H3-233 ENSP00000434650 ENST00000531660	E9PPA1 [Direct mapping] Oxysterols receptor LXR-alpha Show all	SPOCTOPUS predicted secreted proteins Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all		167 aa 18.6 kDa	No	0
NR1H3-235 ENSP00000477707 ENST00000616973	B4DXU5 [Direct mapping] Oxysterols receptor LXR-alpha; cDNA FLJ56172, highly similar to Oxysterols receptor LXR-alpha Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Show all	GO:0000122 [negative regulation of transcription from RNA polymerase II promoter] GO:0000978 [RNA polymerase II proximal promoter sequence-specific DNA binding] GO:0001077 [transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding] GO:0003677 [DNA binding] GO:0003700 [DNA binding transcription factor activity] GO:0003707 [steroid hormone receptor activity] GO:0004879 [nuclear receptor activity] GO:0005634 [nucleus] GO:0006351 [transcription, DNA-templated] GO:0006355 [regulation of transcription, DNA-templated] GO:0006366 [transcription from RNA polymerase II promoter] GO:0008270 [zinc ion binding] GO:0010875 [positive regulation of cholesterol efflux] GO:0010887 [negative regulation of cholesterol storage] GO:0030522 [intracellular receptor signaling pathway] GO:0042632 [cholesterol homeostasis] GO:0043031 [negative regulation of macrophage activation] GO:0043401 [steroid hormone mediated signaling pathway] GO:0043565 [sequence-specific DNA binding] GO:0044212 [transcription regulatory region DNA binding] GO:0044255 [cellular lipid metabolic process] GO:0045861 [negative regulation of proteolysis] GO:0045892 [negative regulation of transcription, DNA-templated] GO:0045893 [positive regulation of transcription, DNA-templated] GO:0045944 [positive regulation of transcription from RNA polymerase II promoter] GO:0046872 [metal ion binding] GO:0050728 [negative regulation of inflammatory response] GO:0055088 [lipid homeostasis] GO:0055092 [sterol homeostasis] GO:0070328 [triglyceride homeostasis] GO:0071222 [cellular response to lipopolysaccharide] GO:0090188 [negative regulation of pancreatic juice secretion] GO:0090341 [negative regulation of secretion of lysosomal enzymes] GO:0090575 [RNA polymerase II transcription factor complex] GO:2000188 [regulation of cholesterol homeostasis] Show all	453 aa 51.1 kDa	No	0

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The Human Protein Atlas

The Human Protein Atlas project is funded
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