Cell type atlas - RNF216 - The Human Protein Atlas

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RNF216

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RNF216
Gene descriptionⁱ Full gene name according to HGNC.	Ring finger protein 216
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids, Early spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids, Early spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	6 NX
Lung	6 NX

Alveolar cells type 2	19 NX
Lung	19 NX

B-cells	11 NX
Colon	19 NX
Kidney	13 NX
Liver	4 NX

Basal glandular cells	17 NX
Prostate	17 NX

Basal keratinocytes	15 NX
Skin	15 NX

Bipolar cells	36 NX
Eye	36 NX

Cardiomyocytes	26 NX
Heart muscle	26 NX

Cholangiocytes	5 NX
Liver	5 NX

Ciliated cells	13 NX
Lung	13 NX

Club cells	15 NX
Lung	15 NX

Collecting duct cells	12 NX
Kidney	12 NX

Cone photoreceptor cells	49 NX
Eye	49 NX

Cytotrophoblasts	12 NX
Placenta	12 NX

Distal tubular cells	22 NX
Kidney	22 NX

Ductal cells	15 NX
Pancreas	15 NX

Early spermatids	119 NX
Testis	119 NX

Endothelial cells	25 NX
Heart muscle	33 NX
Testis	29 NX
Prostate	27 NX
Placenta	25 NX
Pancreas	25 NX
Eye	23 NX
Skin	23 NX
Lung	18 NX
Liver	16 NX

Enterocytes	10 NX
Rectum	10 NX
Colon	10 NX
Small intestine	10 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	12 NX
Pancreas	12 NX

Extravillous trophoblasts	11 NX
Placenta	11 NX

Fibroblasts	21 NX
Prostate	24 NX
Heart muscle	22 NX
Skin	22 NX
Lung	21 NX
Placenta	16 NX

Glandular cells	16 NX
Prostate	16 NX

Granulocytes	19 NX
Lung	28 NX
Colon	9 NX

Hepatocytes	13 NX
Liver	13 NX

Hofbauer cells	19 NX
Placenta	19 NX

Horizontal cells	27 NX
Eye	27 NX

Intestinal endocrine cells	6 NX
Colon	7 NX
Rectum	5 NX

Ito cells	24 NX
Liver	24 NX

Kupffer cells	19 NX
Liver	19 NX

Late spermatids	171 NX
Testis	171 NX

Leydig cells	35 NX
Testis	35 NX

Macrophages	24 NX
Skin	28 NX
Lung	27 NX
Kidney	22 NX
Testis	19 NX
Pancreas	16 NX
Prostate	14 NX

Melanocytes	12 NX
Skin	12 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	33 NX
Pancreas	33 NX

Mucus-secreting cells	13 NX
Small intestine	22 NX
Colon	12 NX
Rectum	10 NX

Muller glia cells	36 NX
Eye	36 NX

Pancreatic endocrine cells	13 NX
Pancreas	13 NX

Paneth cells	4 NX
Rectum	13 NX
Small intestine	4 NX
Colon	3 NX

Peritubular cells	28 NX
Testis	28 NX

Proximal tubular cells	11 NX
Kidney	11 NX

Rod photoreceptor cells	49 NX
Eye	49 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	23 NX
Heart muscle	39 NX
Skin	25 NX
Prostate	19 NX
Pancreas	18 NX

Spermatocytes	97 NX
Testis	97 NX

Spermatogonia	99 NX
Testis	99 NX

Suprabasal keratinocytes	14 NX
Skin	14 NX

Syncytiotrophoblasts	13 NX
Placenta	13 NX

T-cells	23 NX
Lung	46 NX
Skin	39 NX
Colon	35 NX
Kidney	23 NX
Prostate	18 NX
Liver	18 NX

Undifferentiated cells	11 NX
Rectum	11 NX
Small intestine	9 NX
Colon	7 NX

Urothelial cells	13 NX
Prostate	13 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.