Cell type atlas - IDS - The Human Protein Atlas

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IDS

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IDS
Gene descriptionⁱ Full gene name according to HGNC.	Iduronate 2-sulfatase
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	4

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	92 NX
Lung	92 NX

Alveolar cells type 2	66 NX
Lung	66 NX

B-cells	80 NX
Colon	276 NX
Liver	69 NX
Kidney	62 NX

Basal glandular cells	47 NX
Prostate	47 NX

Basal keratinocytes	30 NX
Skin	30 NX

Bipolar cells	173 NX
Eye	173 NX

Cardiomyocytes	42 NX
Heart muscle	42 NX

Cholangiocytes	8 NX
Liver	8 NX

Ciliated cells	79 NX
Lung	79 NX

Club cells	63 NX
Lung	63 NX

Collecting duct cells	79 NX
Kidney	79 NX

Cone photoreceptor cells	43 NX
Eye	43 NX

Cytotrophoblasts	24 NX
Placenta	24 NX

Distal tubular cells	18 NX
Kidney	18 NX

Ductal cells	43 NX
Pancreas	43 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	38 NX
Eye	83 NX
Liver	65 NX
Lung	55 NX
Skin	53 NX
Heart muscle	32 NX
Prostate	32 NX
Testis	31 NX
Placenta	14 NX
Pancreas	14 NX

Enterocytes	37 NX
Rectum	80 NX
Small intestine	48 NX
Colon	20 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	65 NX
Pancreas	65 NX

Extravillous trophoblasts	20 NX
Placenta	20 NX

Fibroblasts	74 NX
Lung	114 NX
Prostate	110 NX
Skin	81 NX
Heart muscle	74 NX
Placenta	17 NX

Glandular cells	59 NX
Prostate	59 NX

Granulocytes	221 NX
Colon	230 NX
Lung	212 NX

Hepatocytes	30 NX
Liver	30 NX

Hofbauer cells	43 NX
Placenta	43 NX

Horizontal cells	210 NX
Eye	210 NX

Intestinal endocrine cells	162 NX
Colon	167 NX
Rectum	157 NX

Ito cells	51 NX
Liver	51 NX

Kupffer cells	68 NX
Liver	68 NX

Late spermatids	2 NX
Testis	2 NX

Leydig cells	67 NX
Testis	67 NX

Macrophages	79 NX
Lung	109 NX
Skin	87 NX
Testis	80 NX
Pancreas	77 NX
Kidney	69 NX
Prostate	52 NX

Melanocytes	49 NX
Skin	49 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	118 NX
Pancreas	118 NX

Mucus-secreting cells	26 NX
Small intestine	37 NX
Rectum	23 NX
Colon	19 NX

Muller glia cells	43 NX
Eye	43 NX

Pancreatic endocrine cells	67 NX
Pancreas	67 NX

Paneth cells	46 NX
Colon	63 NX
Small intestine	46 NX
Rectum	27 NX

Peritubular cells	84 NX
Testis	84 NX

Proximal tubular cells	19 NX
Kidney	19 NX

Rod photoreceptor cells	58 NX
Eye	58 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	65 NX
Prostate	81 NX
Skin	75 NX
Heart muscle	64 NX
Pancreas	22 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	5 NX
Testis	5 NX

Suprabasal keratinocytes	38 NX
Skin	38 NX

Syncytiotrophoblasts	120 NX
Placenta	120 NX

T-cells	114 NX
Colon	259 NX
Skin	157 NX
Prostate	140 NX
Lung	114 NX
Liver	95 NX
Kidney	64 NX

Undifferentiated cells	18 NX
Rectum	18 NX
Small intestine	14 NX
Colon	11 NX

Urothelial cells	87 NX
Prostate	87 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.