Cell type atlas - IL32 - The Human Protein Atlas

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IL32

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IL32
Gene descriptionⁱ Full gene name according to HGNC.	Interleukin 32
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Plasma proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Secreted
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	30

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Pancreatic endocrine cells, Proximal tubular cells, Enterocytes, Ductal cells, Exocrine glandular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (T-reg)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (CACO-2, CAPAN-2, HDLM-2, Hep G2, Karpas-707, MOLT-4, RH-30, U-937)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in many
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level
Extracellular locationⁱ A possible secretion of the protein was predicted based on N-terminal signal sequence (signal peptide) predictions and transmembrane region predictions, and subsequently annotated for its local or systemic secretion based on literature, function, and protein and RNA expression data. Read more	Protein predicted to be secreted

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Pancreatic endocrine cells, Proximal tubular cells, Enterocytes, Ductal cells, Exocrine glandular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	185 NX
Lung	185 NX

Alveolar cells type 2	95 NX
Lung	95 NX

B-cells	39 NX
Kidney	441 NX
Colon	54 NX
Liver	12 NX

Basal glandular cells	79 NX
Prostate	79 NX

Basal keratinocytes	53 NX
Skin	53 NX

Bipolar cells	0 NX
Eye	0 NX

Cardiomyocytes	2 NX
Heart muscle	2 NX

Cholangiocytes	257 NX
Liver	257 NX

Ciliated cells	12 NX
Lung	12 NX

Club cells	23 NX
Lung	23 NX

Collecting duct cells	113 NX
Kidney	113 NX

Cone photoreceptor cells	0 NX
Eye	0 NX

Cytotrophoblasts	1 NX
Placenta	1 NX

Distal tubular cells	214 NX
Kidney	214 NX

Ductal cells	1463 NX
Pancreas	1463 NX

Early spermatids	0 NX
Testis	0 NX

Endothelial cells	121 NX
Pancreas	1236 NX
Skin	257 NX
Lung	257 NX
Placenta	172 NX
Prostate	121 NX
Heart muscle	57 NX
Testis	33 NX
Eye	32 NX
Liver	7 NX

Enterocytes	1496 NX
Small intestine	3467 NX
Colon	798 NX
Rectum	735 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	1263 NX
Pancreas	1263 NX

Extravillous trophoblasts	8 NX
Placenta	8 NX

Fibroblasts	41 NX
Prostate	409 NX
Skin	199 NX
Lung	41 NX
Heart muscle	29 NX
Placenta	24 NX

Glandular cells	85 NX
Prostate	85 NX

Granulocytes	52 NX
Colon	64 NX
Lung	40 NX

Hepatocytes	81 NX
Liver	81 NX

Hofbauer cells	4 NX
Placenta	4 NX

Horizontal cells	0 NX
Eye	0 NX

Intestinal endocrine cells	130 NX
Rectum	147 NX
Colon	112 NX

Ito cells	68 NX
Liver	68 NX

Kupffer cells	41 NX
Liver	41 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	33 NX
Testis	33 NX

Macrophages	50 NX
Kidney	394 NX
Skin	95 NX
Pancreas	49 NX
Lung	28 NX
Prostate	15 NX
Testis	1 NX

Melanocytes	62 NX
Skin	62 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	345 NX
Pancreas	345 NX

Mucus-secreting cells	194 NX
Small intestine	493 NX
Colon	228 NX
Rectum	59 NX

Muller glia cells	0 NX
Eye	0 NX

Pancreatic endocrine cells	3369 NX
Pancreas	3369 NX

Paneth cells	645 NX
Colon	1900 NX
Small intestine	645 NX
Rectum	135 NX

Peritubular cells	43 NX
Testis	43 NX

Proximal tubular cells	2476 NX
Kidney	2476 NX

Rod photoreceptor cells	1 NX
Eye	1 NX

Sertoli cells	19 NX
Testis	19 NX

Smooth muscle cells	101 NX
Pancreas	594 NX
Prostate	101 NX
Skin	98 NX
Heart muscle	6 NX

Spermatocytes	1 NX
Testis	1 NX

Spermatogonia	1 NX
Testis	1 NX

Suprabasal keratinocytes	45 NX
Skin	45 NX

Syncytiotrophoblasts	6 NX
Placenta	6 NX

T-cells	784 NX
Kidney	3872 NX
Skin	2683 NX
Colon	821 NX
Lung	784 NX
Prostate	410 NX
Liver	282 NX

Undifferentiated cells	80 NX
Small intestine	284 NX
Colon	172 NX
Rectum	41 NX

Urothelial cells	81 NX
Prostate	81 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.