Cell type atlas - IFRD1 - The Human Protein Atlas

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IFRD1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	IFRD1
Gene descriptionⁱ Full gene name according to HGNC.	Interferon related developmental regulator 1
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	12

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (neutrophil, eosinophil)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	32 NX
Lung	32 NX

B-cells	26 NX
Colon	128 NX
Liver	26 NX
Kidney	18 NX

Basal glandular cells	140 NX
Prostate	140 NX

Basal keratinocytes	175 NX
Skin	175 NX

Bipolar cells	48 NX
Eye	48 NX

Cardiomyocytes	50 NX
Heart muscle	50 NX

Cholangiocytes	23 NX
Liver	23 NX

Ciliated cells	13 NX
Lung	13 NX

Club cells	33 NX
Lung	33 NX

Collecting duct cells	17 NX
Kidney	17 NX

Cone photoreceptor cells	84 NX
Eye	84 NX

Cytotrophoblasts	64 NX
Placenta	64 NX

Distal tubular cells	15 NX
Kidney	15 NX

Ductal cells	42 NX
Pancreas	42 NX

Early spermatids	32 NX
Testis	32 NX

Endothelial cells	55 NX
Prostate	168 NX
Skin	163 NX
Eye	147 NX
Placenta	57 NX
Testis	55 NX
Pancreas	43 NX
Heart muscle	38 NX
Liver	32 NX
Lung	26 NX

Enterocytes	231 NX
Colon	386 NX
Small intestine	184 NX
Rectum	117 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	50 NX
Pancreas	50 NX

Extravillous trophoblasts	53 NX
Placenta	53 NX

Fibroblasts	71 NX
Prostate	260 NX
Skin	196 NX
Heart muscle	71 NX
Lung	53 NX
Placenta	38 NX

Glandular cells	123 NX
Prostate	123 NX

Granulocytes	76 NX
Colon	138 NX
Lung	14 NX

Hepatocytes	19 NX
Liver	19 NX

Hofbauer cells	104 NX
Placenta	104 NX

Horizontal cells	21 NX
Eye	21 NX

Intestinal endocrine cells	133 NX
Colon	197 NX
Rectum	68 NX

Ito cells	48 NX
Liver	48 NX

Kupffer cells	77 NX
Liver	77 NX

Late spermatids	8 NX
Testis	7 NX

Leydig cells	34 NX
Testis	34 NX

Macrophages	79 NX
Prostate	220 NX
Skin	129 NX
Testis	106 NX
Kidney	52 NX
Pancreas	42 NX
Lung	40 NX

Melanocytes	98 NX
Skin	98 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	73 NX
Pancreas	73 NX

Mucus-secreting cells	83 NX
Colon	301 NX
Small intestine	129 NX
Rectum	59 NX

Muller glia cells	23 NX
Eye	23 NX

Pancreatic endocrine cells	51 NX
Pancreas	51 NX

Paneth cells	211 NX
Colon	449 NX
Small intestine	211 NX
Rectum	113 NX

Peritubular cells	39 NX
Testis	39 NX

Proximal tubular cells	11 NX
Kidney	11 NX

Rod photoreceptor cells	73 NX
Eye	73 NX

Sertoli cells	39 NX
Testis	39 NX

Smooth muscle cells	198 NX
Skin	293 NX
Prostate	229 NX
Pancreas	55 NX
Heart muscle	53 NX

Spermatocytes	14 NX
Testis	14 NX

Spermatogonia	12 NX
Testis	12 NX

Suprabasal keratinocytes	110 NX
Skin	110 NX

Syncytiotrophoblasts	127 NX
Placenta	127 NX

T-cells	55 NX
Colon	150 NX
Prostate	148 NX
Skin	128 NX
Liver	54 NX
Kidney	34 NX
Lung	29 NX

Undifferentiated cells	88 NX
Colon	226 NX
Small intestine	100 NX
Rectum	64 NX

Urothelial cells	126 NX
Prostate	126 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.