Cell type atlas - GDE1 - The Human Protein Atlas

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GDE1

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GDE1
Gene descriptionⁱ Full gene name according to HGNC.	Glycerophosphodiester phosphodiesterase 1
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Syncytiotrophoblasts)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Syncytiotrophoblasts)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	36 NX
Lung	36 NX

Alveolar cells type 2	72 NX
Lung	72 NX

B-cells	28 NX
Colon	40 NX
Liver	28 NX
Kidney	13 NX

Basal glandular cells	29 NX
Prostate	29 NX

Basal keratinocytes	21 NX
Skin	21 NX

Bipolar cells	15 NX
Eye	15 NX

Cardiomyocytes	64 NX
Heart muscle	64 NX

Cholangiocytes	36 NX
Liver	36 NX

Ciliated cells	27 NX
Lung	27 NX

Club cells	26 NX
Lung	26 NX

Collecting duct cells	9 NX
Kidney	9 NX

Cone photoreceptor cells	26 NX
Eye	26 NX

Cytotrophoblasts	64 NX
Placenta	64 NX

Distal tubular cells	20 NX
Kidney	20 NX

Ductal cells	80 NX
Pancreas	79 NX

Early spermatids	28 NX
Testis	28 NX

Endothelial cells	17 NX
Testis	21 NX
Eye	20 NX
Placenta	19 NX
Pancreas	18 NX
Prostate	17 NX
Skin	17 NX
Liver	11 NX
Heart muscle	10 NX
Lung	9 NX

Enterocytes	94 NX
Rectum	138 NX
Colon	94 NX
Small intestine	89 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	143 NX
Pancreas	143 NX

Extravillous trophoblasts	66 NX
Placenta	66 NX

Fibroblasts	28 NX
Heart muscle	35 NX
Placenta	33 NX
Skin	27 NX
Prostate	26 NX
Lung	23 NX

Glandular cells	77 NX
Prostate	77 NX

Granulocytes	4 NX
Lung	7 NX
Colon	0 NX

Hepatocytes	20 NX
Liver	20 NX

Hofbauer cells	53 NX
Placenta	53 NX

Horizontal cells	30 NX
Eye	30 NX

Intestinal endocrine cells	32 NX
Colon	41 NX
Rectum	23 NX

Ito cells	18 NX
Liver	18 NX

Kupffer cells	31 NX
Liver	31 NX

Late spermatids	52 NX
Testis	52 NX

Leydig cells	26 NX
Testis	26 NX

Macrophages	33 NX
Lung	44 NX
Pancreas	37 NX
Testis	36 NX
Kidney	34 NX
Skin	25 NX
Prostate	23 NX

Melanocytes	24 NX
Skin	24 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	23 NX
Pancreas	23 NX

Mucus-secreting cells	51 NX
Rectum	61 NX
Colon	50 NX
Small intestine	48 NX

Muller glia cells	20 NX
Eye	20 NX

Pancreatic endocrine cells	67 NX
Pancreas	67 NX

Paneth cells	88 NX
Colon	92 NX
Small intestine	88 NX
Rectum	85 NX

Peritubular cells	36 NX
Testis	36 NX

Proximal tubular cells	39 NX
Kidney	39 NX

Rod photoreceptor cells	22 NX
Eye	21 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	26 NX
Pancreas	38 NX
Prostate	29 NX
Skin	22 NX
Heart muscle	21 NX

Spermatocytes	71 NX
Testis	71 NX

Spermatogonia	39 NX
Testis	39 NX

Suprabasal keratinocytes	26 NX
Skin	26 NX

Syncytiotrophoblasts	226 NX
Placenta	226 NX

T-cells	22 NX
Colon	45 NX
Liver	27 NX
Prostate	22 NX
Skin	21 NX
Kidney	18 NX
Lung	17 NX

Undifferentiated cells	61 NX
Colon	87 NX
Rectum	63 NX
Small intestine	55 NX

Urothelial cells	49 NX
Prostate	49 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.