Cell type atlas - RHBDD2 - The Human Protein Atlas

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RHBDD2

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	RHBDD2
Gene descriptionⁱ Full gene name according to HGNC.	Rhomboid domain containing 2
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Enzymes
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	3

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Late spermatids)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Late spermatids)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	39 NX
Lung	39 NX

Alveolar cells type 2	29 NX
Lung	29 NX

B-cells	20 NX
Colon	37 NX
Liver	20 NX
Kidney	9 NX

Basal glandular cells	41 NX
Prostate	41 NX

Basal keratinocytes	21 NX
Skin	21 NX

Bipolar cells	34 NX
Eye	34 NX

Cardiomyocytes	8 NX
Heart muscle	8 NX

Cholangiocytes	54 NX
Liver	54 NX

Ciliated cells	47 NX
Lung	47 NX

Club cells	40 NX
Lung	40 NX

Collecting duct cells	82 NX
Kidney	82 NX

Cone photoreceptor cells	31 NX
Eye	31 NX

Cytotrophoblasts	45 NX
Placenta	45 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	80 NX
Pancreas	80 NX

Early spermatids	128 NX
Testis	128 NX

Endothelial cells	24 NX
Pancreas	54 NX
Skin	40 NX
Placenta	34 NX
Prostate	28 NX
Testis	24 NX
Heart muscle	13 NX
Lung	12 NX
Liver	11 NX
Eye	5 NX

Enterocytes	41 NX
Rectum	48 NX
Small intestine	44 NX
Colon	40 NX

Erythroid cells	0 NX
Liver	0 NX

Exocrine glandular cells	90 NX
Pancreas	90 NX

Extravillous trophoblasts	35 NX
Placenta	35 NX

Fibroblasts	36 NX
Placenta	51 NX
Skin	39 NX
Prostate	36 NX
Lung	18 NX
Heart muscle	13 NX

Glandular cells	53 NX
Prostate	53 NX

Granulocytes	189 NX
Colon	220 NX
Lung	158 NX

Hepatocytes	35 NX
Liver	35 NX

Hofbauer cells	39 NX
Placenta	39 NX

Horizontal cells	18 NX
Eye	18 NX

Intestinal endocrine cells	86 NX
Colon	95 NX
Rectum	77 NX

Ito cells	66 NX
Liver	66 NX

Kupffer cells	29 NX
Liver	29 NX

Late spermatids	233 NX
Testis	233 NX

Leydig cells	39 NX
Testis	39 NX

Macrophages	32 NX
Pancreas	190 NX
Lung	67 NX
Prostate	65 NX
Kidney	33 NX
Skin	28 NX
Testis	21 NX

Melanocytes	57 NX
Skin	57 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	22 NX
Pancreas	22 NX

Mucus-secreting cells	32 NX
Small intestine	38 NX
Colon	29 NX
Rectum	26 NX

Muller glia cells	63 NX
Eye	63 NX

Pancreatic endocrine cells	61 NX
Pancreas	61 NX

Paneth cells	32 NX
Colon	43 NX
Small intestine	32 NX
Rectum	27 NX

Peritubular cells	50 NX
Testis	50 NX

Proximal tubular cells	44 NX
Kidney	44 NX

Rod photoreceptor cells	28 NX
Eye	28 NX

Sertoli cells	7 NX
Testis	7 NX

Smooth muscle cells	25 NX
Pancreas	58 NX
Prostate	31 NX
Skin	18 NX
Heart muscle	11 NX

Spermatocytes	39 NX
Testis	39 NX

Spermatogonia	30 NX
Testis	30 NX

Suprabasal keratinocytes	21 NX
Skin	21 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	44 NX
Prostate	205 NX
Colon	96 NX
Skin	75 NX
Kidney	47 NX
Lung	42 NX
Liver	26 NX

Undifferentiated cells	24 NX
Colon	32 NX
Small intestine	28 NX
Rectum	23 NX

Urothelial cells	42 NX
Prostate	42 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.