Cell type atlas - POLR2J - The Human Protein Atlas

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POLR2J

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	POLR2J
Gene descriptionⁱ Full gene name according to HGNC.	RNA polymerase II subunit J
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	RNA polymerase related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	2

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	33 NX
Lung	33 NX

Alveolar cells type 2	38 NX
Lung	38 NX

B-cells	101 NX
Kidney	116 NX
Liver	112 NX
Colon	87 NX

Basal glandular cells	100 NX
Prostate	100 NX

Basal keratinocytes	84 NX
Skin	84 NX

Bipolar cells	37 NX
Eye	37 NX

Cardiomyocytes	165 NX
Heart muscle	165 NX

Cholangiocytes	71 NX
Liver	71 NX

Ciliated cells	70 NX
Lung	70 NX

Club cells	36 NX
Lung	36 NX

Collecting duct cells	119 NX
Kidney	119 NX

Cone photoreceptor cells	12 NX
Eye	12 NX

Cytotrophoblasts	176 NX
Placenta	176 NX

Distal tubular cells	232 NX
Kidney	232 NX

Ductal cells	122 NX
Pancreas	122 NX

Early spermatids	40 NX
Testis	40 NX

Endothelial cells	91 NX
Placenta	135 NX
Pancreas	122 NX
Liver	106 NX
Skin	93 NX
Testis	93 NX
Heart muscle	78 NX
Prostate	65 NX
Eye	62 NX
Lung	32 NX

Enterocytes	190 NX
Colon	251 NX
Small intestine	193 NX
Rectum	164 NX

Erythroid cells	140 NX
Liver	140 NX

Exocrine glandular cells	174 NX
Pancreas	173 NX

Extravillous trophoblasts	165 NX
Placenta	165 NX

Fibroblasts	101 NX
Heart muscle	125 NX
Placenta	124 NX
Skin	100 NX
Prostate	60 NX
Lung	46 NX

Glandular cells	117 NX
Prostate	117 NX

Granulocytes	43 NX
Colon	46 NX
Lung	40 NX

Hepatocytes	165 NX
Liver	165 NX

Hofbauer cells	176 NX
Placenta	176 NX

Horizontal cells	33 NX
Eye	33 NX

Intestinal endocrine cells	99 NX
Colon	102 NX
Rectum	96 NX

Ito cells	85 NX
Liver	85 NX

Kupffer cells	98 NX
Liver	97 NX

Late spermatids	34 NX
Testis	34 NX

Leydig cells	118 NX
Testis	118 NX

Macrophages	117 NX
Pancreas	178 NX
Kidney	163 NX
Testis	129 NX
Prostate	119 NX
Skin	105 NX
Lung	48 NX

Melanocytes	135 NX
Skin	135 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	153 NX
Pancreas	153 NX

Mucus-secreting cells	116 NX
Colon	206 NX
Small intestine	127 NX
Rectum	106 NX

Muller glia cells	98 NX
Eye	98 NX

Pancreatic endocrine cells	156 NX
Pancreas	156 NX

Paneth cells	165 NX
Colon	472 NX
Small intestine	165 NX
Rectum	116 NX

Peritubular cells	104 NX
Testis	104 NX

Proximal tubular cells	181 NX
Kidney	181 NX

Rod photoreceptor cells	35 NX
Eye	35 NX

Sertoli cells	52 NX
Testis	52 NX

Smooth muscle cells	107 NX
Heart muscle	174 NX
Pancreas	167 NX
Skin	100 NX
Prostate	73 NX

Spermatocytes	95 NX
Testis	95 NX

Spermatogonia	244 NX
Testis	244 NX

Suprabasal keratinocytes	102 NX
Skin	102 NX

Syncytiotrophoblasts	152 NX
Placenta	152 NX

T-cells	76 NX
Kidney	128 NX
Colon	110 NX
Skin	108 NX
Liver	72 NX
Lung	42 NX
Prostate	39 NX

Undifferentiated cells	104 NX
Colon	151 NX
Small intestine	104 NX
Rectum	93 NX

Urothelial cells	131 NX
Prostate	131 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.