Cell type atlas - SLC25A5 - The Human Protein Atlas

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SLC25A5

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	SLC25A5
Gene descriptionⁱ Full gene name according to HGNC.	Solute carrier family 25 member 5
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	FDA approved drug targets Plasma proteins Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	1

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Distal tubular cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Distal tubular cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	152 NX
Lung	152 NX

Alveolar cells type 2	245 NX
Lung	245 NX

B-cells	336 NX
Liver	480 NX
Colon	349 NX
Kidney	227 NX

Basal glandular cells	402 NX
Prostate	402 NX

Basal keratinocytes	725 NX
Skin	725 NX

Bipolar cells	105 NX
Eye	105 NX

Cardiomyocytes	126 NX
Heart muscle	126 NX

Cholangiocytes	329 NX
Liver	329 NX

Ciliated cells	187 NX
Lung	187 NX

Club cells	222 NX
Lung	222 NX

Collecting duct cells	178 NX
Kidney	178 NX

Cone photoreceptor cells	57 NX
Eye	57 NX

Cytotrophoblasts	945 NX
Placenta	945 NX

Distal tubular cells	2147 NX
Kidney	2147 NX

Ductal cells	467 NX
Pancreas	467 NX

Early spermatids	3 NX
Testis	3 NX

Endothelial cells	210 NX
Prostate	530 NX
Skin	375 NX
Pancreas	290 NX
Placenta	282 NX
Testis	210 NX
Liver	182 NX
Eye	149 NX
Lung	117 NX
Heart muscle	115 NX

Enterocytes	1628 NX
Small intestine	2433 NX
Rectum	1528 NX
Colon	669 NX

Erythroid cells	164 NX
Liver	164 NX

Exocrine glandular cells	919 NX
Pancreas	919 NX

Extravillous trophoblasts	322 NX
Placenta	322 NX

Fibroblasts	246 NX
Prostate	402 NX
Skin	248 NX
Placenta	225 NX
Lung	215 NX
Heart muscle	108 NX

Glandular cells	228 NX
Prostate	228 NX

Granulocytes	191 NX
Colon	257 NX
Lung	126 NX

Hepatocytes	343 NX
Liver	343 NX

Hofbauer cells	786 NX
Placenta	786 NX

Horizontal cells	25 NX
Eye	25 NX

Intestinal endocrine cells	385 NX
Rectum	393 NX
Colon	377 NX

Ito cells	119 NX
Liver	119 NX

Kupffer cells	477 NX
Liver	477 NX

Late spermatids	14 NX
Testis	14 NX

Leydig cells	135 NX
Testis	135 NX

Macrophages	448 NX
Prostate	779 NX
Pancreas	676 NX
Kidney	502 NX
Skin	487 NX
Testis	393 NX
Lung	278 NX

Melanocytes	520 NX
Skin	520 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	300 NX
Pancreas	300 NX

Mucus-secreting cells	755 NX
Colon	860 NX
Rectum	756 NX
Small intestine	648 NX

Muller glia cells	85 NX
Eye	85 NX

Pancreatic endocrine cells	524 NX
Pancreas	524 NX

Paneth cells	956 NX
Colon	1313 NX
Rectum	956 NX
Small intestine	586 NX

Peritubular cells	104 NX
Testis	104 NX

Proximal tubular cells	1138 NX
Kidney	1138 NX

Rod photoreceptor cells	131 NX
Eye	131 NX

Sertoli cells	129 NX
Testis	129 NX

Smooth muscle cells	460 NX
Prostate	519 NX
Skin	487 NX
Pancreas	413 NX
Heart muscle	294 NX

Spermatocytes	9 NX
Testis	9 NX

Spermatogonia	117 NX
Testis	117 NX

Suprabasal keratinocytes	839 NX
Skin	839 NX

Syncytiotrophoblasts	1329 NX
Placenta	1329 NX

T-cells	292 NX
Skin	471 NX
Colon	338 NX
Liver	319 NX
Prostate	292 NX
Kidney	240 NX
Lung	194 NX

Undifferentiated cells	959 NX
Small intestine	1111 NX
Rectum	922 NX
Colon	764 NX

Urothelial cells	658 NX
Prostate	658 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.