Cell type atlas - M6PR - The Human Protein Atlas

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M6PR

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	M6PR
Gene descriptionⁱ Full gene name according to HGNC.	Mannose-6-phosphate receptor, cation dependent
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	FDA approved drug targets Transporters
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular,Membrane
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (monocytes, Hofbauer cells)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (HDLM-2)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (monocytes, Hofbauer cells)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	54 NX
Lung	54 NX

Alveolar cells type 2	54 NX
Lung	54 NX

B-cells	74 NX
Colon	97 NX
Kidney	85 NX
Liver	52 NX

Basal glandular cells	61 NX
Prostate	61 NX

Basal keratinocytes	39 NX
Skin	39 NX

Bipolar cells	44 NX
Eye	44 NX

Cardiomyocytes	9 NX
Heart muscle	9 NX

Cholangiocytes	18 NX
Liver	18 NX

Ciliated cells	60 NX
Lung	60 NX

Club cells	69 NX
Lung	69 NX

Collecting duct cells	30 NX
Kidney	30 NX

Cone photoreceptor cells	22 NX
Eye	22 NX

Cytotrophoblasts	56 NX
Placenta	56 NX

Distal tubular cells	17 NX
Kidney	17 NX

Ductal cells	78 NX
Pancreas	78 NX

Early spermatids	6 NX
Testis	6 NX

Endothelial cells	32 NX
Pancreas	68 NX
Eye	55 NX
Prostate	41 NX
Testis	40 NX
Skin	34 NX
Placenta	32 NX
Lung	32 NX
Liver	20 NX
Heart muscle	3 NX

Enterocytes	19 NX
Rectum	27 NX
Small intestine	22 NX
Colon	15 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	58 NX
Pancreas	58 NX

Extravillous trophoblasts	59 NX
Placenta	59 NX

Fibroblasts	32 NX
Prostate	48 NX
Placenta	40 NX
Lung	37 NX
Skin	28 NX
Heart muscle	16 NX

Glandular cells	49 NX
Prostate	49 NX

Granulocytes	127 NX
Lung	154 NX
Colon	101 NX

Hepatocytes	23 NX
Liver	23 NX

Hofbauer cells	215 NX
Placenta	215 NX

Horizontal cells	52 NX
Eye	52 NX

Intestinal endocrine cells	37 NX
Colon	41 NX
Rectum	33 NX

Ito cells	32 NX
Liver	32 NX

Kupffer cells	111 NX
Liver	111 NX

Late spermatids	5 NX
Testis	5 NX

Leydig cells	33 NX
Testis	33 NX

Macrophages	120 NX
Pancreas	395 NX
Prostate	164 NX
Kidney	139 NX
Lung	133 NX
Testis	101 NX
Skin	80 NX

Melanocytes	64 NX
Skin	64 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	227 NX
Pancreas	227 NX

Mucus-secreting cells	30 NX
Rectum	30 NX
Small intestine	30 NX
Colon	18 NX

Muller glia cells	32 NX
Eye	32 NX

Pancreatic endocrine cells	48 NX
Pancreas	48 NX

Paneth cells	25 NX
Rectum	41 NX
Small intestine	25 NX
Colon	14 NX

Peritubular cells	30 NX
Testis	30 NX

Proximal tubular cells	34 NX
Kidney	34 NX

Rod photoreceptor cells	31 NX
Eye	31 NX

Sertoli cells	26 NX
Testis	26 NX

Smooth muscle cells	45 NX
Pancreas	66 NX
Prostate	45 NX
Skin	40 NX
Heart muscle	8 NX

Spermatocytes	102 NX
Testis	102 NX

Spermatogonia	45 NX
Testis	45 NX

Suprabasal keratinocytes	35 NX
Skin	35 NX

Syncytiotrophoblasts	44 NX
Placenta	44 NX

T-cells	79 NX
Lung	125 NX
Kidney	114 NX
Liver	79 NX
Colon	79 NX
Prostate	61 NX
Skin	57 NX

Undifferentiated cells	42 NX
Colon	44 NX
Rectum	42 NX
Small intestine	42 NX

Urothelial cells	56 NX
Prostate	56 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.