Cell type atlas - BAD - The Human Protein Atlas

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BAD

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	BAD
Gene descriptionⁱ Full gene name according to HGNC.	BCL2 associated agonist of cell death
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Cancer-related genes RAS pathway related proteins
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in all
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Low cell line specificity
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Low cell type specificity

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	30 NX
Lung	30 NX

Alveolar cells type 2	43 NX
Lung	43 NX

B-cells	37 NX
Kidney	58 NX
Colon	34 NX
Liver	27 NX

Basal glandular cells	60 NX
Prostate	60 NX

Basal keratinocytes	92 NX
Skin	92 NX

Bipolar cells	63 NX
Eye	63 NX

Cardiomyocytes	42 NX
Heart muscle	42 NX

Cholangiocytes	64 NX
Liver	64 NX

Ciliated cells	50 NX
Lung	50 NX

Club cells	21 NX
Lung	21 NX

Collecting duct cells	51 NX
Kidney	51 NX

Cone photoreceptor cells	18 NX
Eye	18 NX

Cytotrophoblasts	138 NX
Placenta	138 NX

Distal tubular cells	116 NX
Kidney	116 NX

Ductal cells	88 NX
Pancreas	88 NX

Early spermatids	29 NX
Testis	29 NX

Endothelial cells	45 NX
Skin	85 NX
Placenta	75 NX
Pancreas	61 NX
Testis	59 NX
Liver	45 NX
Prostate	43 NX
Lung	38 NX
Eye	38 NX
Heart muscle	32 NX

Enterocytes	146 NX
Colon	244 NX
Rectum	147 NX
Small intestine	115 NX

Erythroid cells	23 NX
Liver	23 NX

Exocrine glandular cells	96 NX
Pancreas	96 NX

Extravillous trophoblasts	163 NX
Placenta	163 NX

Fibroblasts	113 NX
Skin	142 NX
Placenta	107 NX
Heart muscle	49 NX
Prostate	43 NX
Lung	34 NX

Glandular cells	51 NX
Prostate	51 NX

Granulocytes	24 NX
Colon	37 NX
Lung	12 NX

Hepatocytes	45 NX
Liver	45 NX

Hofbauer cells	64 NX
Placenta	64 NX

Horizontal cells	45 NX
Eye	45 NX

Intestinal endocrine cells	100 NX
Colon	116 NX
Rectum	84 NX

Ito cells	51 NX
Liver	51 NX

Kupffer cells	26 NX
Liver	26 NX

Late spermatids	68 NX
Testis	68 NX

Leydig cells	69 NX
Testis	69 NX

Macrophages	35 NX
Skin	70 NX
Pancreas	56 NX
Kidney	46 NX
Testis	25 NX
Prostate	22 NX
Lung	10 NX

Melanocytes	105 NX
Skin	105 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	70 NX
Pancreas	70 NX

Mucus-secreting cells	94 NX
Colon	195 NX
Rectum	96 NX
Small intestine	84 NX

Muller glia cells	52 NX
Eye	52 NX

Pancreatic endocrine cells	96 NX
Pancreas	96 NX

Paneth cells	140 NX
Colon	300 NX
Small intestine	140 NX
Rectum	124 NX

Peritubular cells	80 NX
Testis	80 NX

Proximal tubular cells	116 NX
Kidney	116 NX

Rod photoreceptor cells	36 NX
Eye	36 NX

Sertoli cells	58 NX
Testis	58 NX

Smooth muscle cells	78 NX
Pancreas	92 NX
Skin	80 NX
Heart muscle	65 NX
Prostate	64 NX

Spermatocytes	88 NX
Testis	88 NX

Spermatogonia	28 NX
Testis	28 NX

Suprabasal keratinocytes	104 NX
Skin	104 NX

Syncytiotrophoblasts	213 NX
Placenta	213 NX

T-cells	44 NX
Skin	63 NX
Colon	56 NX
Kidney	47 NX
Prostate	44 NX
Liver	41 NX
Lung	9 NX

Undifferentiated cells	85 NX
Colon	122 NX
Rectum	114 NX
Small intestine	67 NX

Urothelial cells	56 NX
Prostate	56 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.