Cell type atlas - GCLC - The Human Protein Atlas

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GCLC

SUMMARY

TISSUE

CELL TYPE

PATHOLOGY

BRAIN

BLOOD

CELL

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	GCLC
Gene descriptionⁱ Full gene name according to HGNC.	Glutamate-cysteine ligase catalytic subunit
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Enzymes Plasma proteins Potential drug targets
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	7

HUMAN PROTEIN ATLAS INFORMATIONⁱ Summary of RNA expression and protein localization based on data generated within the Human Protein Atlas project.
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (Intestinal endocrine cells, Hepatocytes)
Blood cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Cell type enhanced (NK-cell)
Blood cell distributionⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Cell line enhanced (A549, Hep G2, OE19, RT4)
Cell line distributionⁱ RNA distribution category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into five different categories (detected in all, detected in many, detected in some, detected in single and not detected) according to their pattern of detected RNA expression across the panel of cell lines.	Detected in all
Protein evidenceⁱ Evidence score for genes based on UniProt protein existence (UniProt evidence); a Human Protein Atlas antibody- or RNA based score (HPA evidence); and evidence based on PeptideAtlas (MS evidence). The avaliable scores are evidence at protein level, evidence at transcript level, no evidence, or not avaliable. Read more	Evidence at protein level

SINGLE CELL TYPESⁱ A summary of single cell RNA (NX) from all single cell types. Color-coding is based on cell type groups, each consisting of cell types with functional features in common.
Single cell types Group Expression Alphabetical RNA single cell type specificity: Cell type enhanced (Intestinal endocrine cells, Hepatocytes)

SINGLE CELL TISSUESⁱ Single cell RNA in cell types from tissue are shown separately for each analyzed tissue. For easier navigation across tissues, use the grey browser on the left side of the window. Barchart shows pTPM levels in each cluster of single cells. To the left, a UMAP plot illustrates the RNA expression profile. The tissue name and plots are clickable and redirect to a more detailed interactive page. Color-coding is based on cell type groups, each consisting of cell types with functional features in common. Please note that the same cell type may be found in several clusters.
Cluster Expression Alphabetical Colon
Cluster Expression Alphabetical Eye
Cluster Expression Alphabetical Heart muscle
Cluster Expression Alphabetical Kidney
Cluster Expression Alphabetical Liver
Cluster Expression Alphabetical Lung
Cluster Expression Alphabetical Pancreas
Cluster Expression Alphabetical Placenta
Cluster Expression Alphabetical Prostate
Cluster Expression Alphabetical Rectum
Cluster Expression Alphabetical Skin
Cluster Expression Alphabetical Small intestine
Cluster Expression Alphabetical Testis

BLOODⁱ

Single cell data

Cluster

Expression

Alphabetical

PBMC

Flow sorted data

Lineage

Expression

Alphabetical

CELL LINESⁱ RNA expression data (NX) of tissue culture cell lines.The analyzed cell lines are divided into 16 color-coded groups according to the organ they were obtained from. Detailed information about a specific cell line is revealed by hovering over the corresponding bar in the chart. The chart is clickable and redirects to more Cell Atlas data. Read more
Organ Expression Alphabetical

Alveolar cells type 1	0 NX
Lung	0 NX

Alveolar cells type 2	4 NX
Lung	4 NX

B-cells	8 NX
Liver	12 NX
Colon	6 NX
Kidney	5 NX

Basal glandular cells	43 NX
Prostate	43 NX

Basal keratinocytes	31 NX
Skin	31 NX

Bipolar cells	13 NX
Eye	13 NX

Cardiomyocytes	18 NX
Heart muscle	18 NX

Cholangiocytes	26 NX
Liver	26 NX

Ciliated cells	48 NX
Lung	48 NX

Club cells	48 NX
Lung	48 NX

Collecting duct cells	0 NX
Kidney	0 NX

Cone photoreceptor cells	24 NX
Eye	24 NX

Cytotrophoblasts	5 NX
Placenta	5 NX

Distal tubular cells	10 NX
Kidney	10 NX

Ductal cells	13 NX
Pancreas	13 NX

Early spermatids	1 NX
Testis	1 NX

Endothelial cells	14 NX
Pancreas	22 NX
Heart muscle	22 NX
Prostate	18 NX
Testis	14 NX
Liver	14 NX
Skin	11 NX
Placenta	7 NX
Eye	7 NX
Lung	3 NX

Enterocytes	20 NX
Colon	31 NX
Small intestine	17 NX
Rectum	12 NX

Erythroid cells	47 NX
Liver	47 NX

Exocrine glandular cells	11 NX
Pancreas	11 NX

Extravillous trophoblasts	7 NX
Placenta	7 NX

Fibroblasts	9 NX
Prostate	17 NX
Heart muscle	13 NX
Skin	11 NX
Lung	4 NX
Placenta	4 NX

Glandular cells	45 NX
Prostate	45 NX

Granulocytes	2 NX
Lung	5 NX
Colon	0 NX

Hepatocytes	102 NX
Liver	102 NX

Hofbauer cells	20 NX
Placenta	20 NX

Horizontal cells	8 NX
Eye	8 NX

Intestinal endocrine cells	212 NX
Rectum	227 NX
Colon	197 NX

Ito cells	9 NX
Liver	9 NX

Kupffer cells	60 NX
Liver	60 NX

Late spermatids	1 NX
Testis	1 NX

Leydig cells	6 NX
Testis	6 NX

Macrophages	16 NX
Prostate	64 NX
Testis	31 NX
Pancreas	28 NX
Kidney	21 NX
Skin	11 NX
Lung	6 NX

Melanocytes	9 NX
Skin	9 NX

Mixed cell types	NX
Pancreas	NX

Mixed immune cells	NX
Heart muscle	NX

Monocytes	6 NX
Pancreas	6 NX

Mucus-secreting cells	16 NX
Small intestine	18 NX
Rectum	17 NX
Colon	16 NX

Muller glia cells	14 NX
Eye	14 NX

Pancreatic endocrine cells	17 NX
Pancreas	17 NX

Paneth cells	9 NX
Colon	23 NX
Rectum	9 NX
Small intestine	4 NX

Peritubular cells	9 NX
Testis	9 NX

Proximal tubular cells	20 NX
Kidney	20 NX

Rod photoreceptor cells	4 NX
Eye	4 NX

Sertoli cells	13 NX
Testis	13 NX

Smooth muscle cells	10 NX
Heart muscle	15 NX
Prostate	12 NX
Skin	7 NX
Pancreas	5 NX

Spermatocytes	3 NX
Testis	3 NX

Spermatogonia	8 NX
Testis	8 NX

Suprabasal keratinocytes	22 NX
Skin	22 NX

Syncytiotrophoblasts	7 NX
Placenta	7 NX

T-cells	11 NX
Colon	16 NX
Skin	11 NX
Kidney	11 NX
Liver	10 NX
Lung	9 NX
Prostate	0 NX

Undifferentiated cells	14 NX
Small intestine	16 NX
Colon	14 NX
Rectum	10 NX

Urothelial cells	89 NX
Prostate	89 NX

Contact

contact@proteinatlas.org

The Project

The Human Protein Atlas

The Human Protein Atlas project is funded
by the Knut & Alice Wallenberg Foundation.