The primary data page shows the detailed antibody staining in 76 different cell types for each analyzed antibody. In addition, for each cell type, a knowledge-based annotated protein expression score based on all analyzed antibodies is displayed furthest to the right. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
The tissues and cell types can be ordered by organ, cell type or alphabetically. If ordered by organ, the tissues are presented in groups according to functional features. If ordered by cell type, the cells are presented in groups related to origin.
This score describes the level of antibody staining observed in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is based on the staining intensity and fraction of stained cells. The images and annotations can be accessed by clicking on the tissue name or score bar. More information can be found in Assays & Annotation.
This score describes a knowledge-based best estimate of the protein expression in the annotated cell types as not detected (n), low (l), medium (m) or high (h). It is a result of stringent evaluation of immunohistochemical staining pattern, RNA data from internal and external sources and available protein/gene characterization data. More information can be found in Assays & Annotation.
Summarizing texts describe the staining pattern for each antibody based on staining intensity, fraction of stained cells and subcellular localization. More information can be found in Assays & Annotation.
Most normal tissues displayed moderate cytoplasmic and/or nuclear positivity with additional membranous positivity in some cases. Salivary gland, urothelial cells, neuronal cells and glandular cells of cervix showed strong positivity.
Normal tissues displayed moderate to strong cytoplasmic staining with often granular pattern. Parathyroid and seminal vesicle were weakly stained.
Neuronal cells and Purkinje cells displayed strong cytoplasmic and nuclear/nucleolar positivity. Ganglion cells showed strong cytoplasmic staining. Small intestine, subset of cells in seminiferus ducts, glandular cells in breast, ovarian follicle cells and fibroblasts were moderately stained. Moderate membranous staining was observed in a fraction of placental trophoblasts. Remaining normal cells were weakly stained or negative.