The version 25 of the Human Protein Atlas has been launched with lots of additional data and new features. Data corresponding to all human protein-coding genes is presented in 9 different resources including protein profiles in cells, tissues, organs and blood. The open access resource now includes more than 10 million manually annotated bioimages and data for over 6 billion assay measurements from 300,000 separate biological samples...Read more

In an article published in PNAS, researchers have used the recombinant expression of more than 2000 Human Secretome Project proteins to investigate the factors influencing recombinant protein expression in CHO cells...Read more

The ability to degrade intracellular proteins in a controlled manner is an important cellular function. It is utilized to remove and recycle unnecessary, damaged and/or harmful components, which is an essential ability to maintain cellular homeostasis and health. The most well-known routes to selective degradation of proteins are proteasomal degradation and selective autophagy. In both pathways, proteins targeted for degradation are marked polyubiquitination (polyUb), with chains that are linked at lysine K48 and K63, respectively...Read more

A new study has mapped the distinct molecular "fingerprints" that 59 diseases leave in an individual's blood protein - which would enable blood tests to discern troubling signs from those that are more common. Publishing today in Science, an international team of researchers mapped how thousands of proteins in human blood shift as a result of aging and serious diseases, such as cancer and cardiovascular and autoimmune diseases...Read more

In the journal Cell, researchers publish a deep analysis of the HPA primary cilia section, first introduced in HPA v24. The HPA subcellular resource portrays primary cilia as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, and inspires many new views on this tiny antenna...Read more