Primary cilia are thin projections that are present on most cell types and that serve critical functions during multiple biological processes, including embryonic development. They are present in a single copy per cell and act much like an antenna, receiving and sending signals to the environment. This makes them crucial for coordinating cellular processes early in life...Read more

In a publication in PLOS One researchers have trained a deep learning model to segment epithelial cells based on their different grades of malignity in breast cancer sections using immunohistochemistry stainings as ground truth...Read more

In a publication in Molecular Systems Biology HPA related researchers review the recent application of AI and systems biology in integrating and interpreting multi-omics data and their contributions to drug discovery. The newly generated longitudinal multi-omics datasets that are needed for these analyses and to enhance precision health and medicine are also described...Read more

Cancer is a leading cause of death in every country of the world and hepatocellular carcinoma (HCC) is third in line in terms of mortality (Sung, 2021). In the past few years, immunotherapy with immune checkpoint inhibitors (ICIs) has become a common treatment route for HCC, but a large proportion of patients are resistant to such treatments...Read more

In an article published in the journal Immunity HPA related researchers have analyzed plasma proteins in adults during and after acute malaria and by integrating the profiles with single-cell RNA-seq data they have been able to link responses to peripheral immune cells and identify a protein profile enriched in severe malaria...Read more