The ability to degrade intracellular proteins in a controlled manner is an important cellular function. It is utilized to remove and recycle unnecessary, damaged and/or harmful components, which is an essential ability to maintain cellular homeostasis and health. The most well-known routes to selective degradation of proteins are proteasomal degradation and selective autophagy. In both pathways, proteins targeted for degradation are marked polyubiquitination (polyUb), with chains that are linked at lysine K48 and K63, respectively...Read more

A new study has mapped the distinct molecular "fingerprints" that 59 diseases leave in an individual's blood protein - which would enable blood tests to discern troubling signs from those that are more common. Publishing today in Science, an international team of researchers mapped how thousands of proteins in human blood shift as a result of aging and serious diseases, such as cancer and cardiovascular and autoimmune diseases...Read more

In the journal Cell, researchers publish a deep analysis of the HPA primary cilia section, first introduced in HPA v24. The HPA subcellular resource portrays primary cilia as the most heterogeneous organelles, customized by the cell for fine-tuned environmental sensing, and inspires many new views on this tiny antenna...Read more

Primary cilia are thin projections that are present on most cell types and that serve critical functions during multiple biological processes, including embryonic development. They are present in a single copy per cell and act much like an antenna, receiving and sending signals to the environment. This makes them crucial for coordinating cellular processes early in life...Read more

In a publication in PLOS One researchers have trained a deep learning model to segment epithelial cells based on their different grades of malignity in breast cancer sections using immunohistochemistry stainings as ground truth...Read more