Gene	"Gene synonym"	Ensembl	"Gene description"	Uniprot	Chromosome	Position	"Protein class"	"Biological process"	"Molecular function"	"Disease involvement"	Evidence	"HPA evidence"	"UniProt evidence"	"NeXtProt evidence"	"MS evidence"	"RNA tissue specificity"	"RNA tissue distribution"	"RNA tissue specificity score"	"RNA tissue specific NX"	"RNA single cell type specificity"	"RNA single cell type distribution"	"RNA single cell type specificity score"	"RNA single cell type specific NX"	"RNA cancer specificity"	"RNA cancer distribution"	"RNA cancer specificity score"	"RNA cancer specific FPKM"	"RNA brain regional specificity"	"RNA brain regional distribution"	"RNA brain regional specificity score"	"RNA brain regional specific NX"	"RNA blood cell specificity"	"RNA blood cell distribution"	"RNA blood cell specificity score"	"RNA blood cell specific NX"	"RNA blood lineage specificity"	"RNA blood lineage distribution"	"RNA blood lineage specificity score"	"RNA blood lineage specific NX"	"RNA cell line specificity"	"RNA cell line distribution"	"RNA cell line specificity score"	"RNA cell line specific NX"	"RNA mouse brain regional specificity"	"RNA mouse brain regional distribution"	"RNA mouse brain regional specificity score"	"RNA mouse brain regional specific pTPM"	"RNA pig brain regional specificity"	"RNA pig brain regional distribution"	"RNA pig brain regional specificity score"	"RNA pig brain regional specific pTPM"	Antibody	"Reliability (IH)"	"Reliability (Mouse Brain)"	"Reliability (IF)"	"Subcellular location"	"Secretome location"	"CCD Protein"	"CCD Transcript"	"Blood concentration - Conc. blood IM [pg/L]"	"Blood concentration - Conc. blood MS [pg/L]"	"Subcellular main location"	"Subcellular additional location"	"Antibody RRID"	"Pathology prognostics - Breast cancer"	"Pathology prognostics - Cervical cancer"	"Pathology prognostics - Colorectal cancer"	"Pathology prognostics - Endometrial cancer"	"Pathology prognostics - Glioma"	"Pathology prognostics - Head and neck cancer"	"Pathology prognostics - Liver cancer"	"Pathology prognostics - Lung cancer"	"Pathology prognostics - Melanoma"	"Pathology prognostics - Ovarian cancer"	"Pathology prognostics - Pancreatic cancer"	"Pathology prognostics - Prostate cancer"	"Pathology prognostics - Renal cancer"	"Pathology prognostics - Stomach cancer"	"Pathology prognostics - Testis cancer"	"Pathology prognostics - Thyroid cancer"	"Pathology prognostics - Urothelial cancer"	"Tissue RNA - adipose tissue [NX]"	"Tissue RNA - adrenal gland [NX]"	"Tissue RNA - amygdala [NX]"	"Tissue RNA - appendix [NX]"	"Tissue RNA - basal ganglia [NX]"	"Tissue RNA - bone marrow [NX]"	"Tissue RNA - breast [NX]"	"Tissue RNA - cerebellum [NX]"	"Tissue RNA - cerebral cortex [NX]"	"Tissue RNA - cervix, uterine [NX]"	"Tissue RNA - colon [NX]"	"Tissue RNA - corpus callosum [NX]"	"Tissue RNA - ductus deferens [NX]"	"Tissue RNA - duodenum [NX]"	"Tissue RNA - endometrium 1 [NX]"	"Tissue RNA - epididymis [NX]"	"Tissue RNA - esophagus [NX]"	"Tissue RNA - fallopian tube [NX]"	"Tissue RNA - gallbladder [NX]"	"Tissue RNA - heart muscle [NX]"	"Tissue RNA - hippocampal formation [NX]"	"Tissue RNA - hypothalamus [NX]"	"Tissue RNA - kidney [NX]"	"Tissue RNA - liver [NX]"	"Tissue RNA - lung [NX]"	"Tissue RNA - lymph node [NX]"	"Tissue RNA - midbrain [NX]"	"Tissue RNA - olfactory region [NX]"	"Tissue RNA - ovary [NX]"	"Tissue RNA - pancreas [NX]"	"Tissue RNA - parathyroid gland [NX]"	"Tissue RNA - pituitary gland [NX]"	"Tissue RNA - placenta [NX]"	"Tissue RNA - pons and medulla [NX]"	"Tissue RNA - prostate [NX]"	"Tissue RNA - rectum [NX]"	"Tissue RNA - retina [NX]"	"Tissue RNA - salivary gland [NX]"	"Tissue RNA - seminal vesicle [NX]"	"Tissue RNA - skeletal muscle [NX]"	"Tissue RNA - skin 1 [NX]"	"Tissue RNA - small intestine [NX]"	"Tissue RNA - smooth muscle [NX]"	"Tissue RNA - spinal cord [NX]"	"Tissue RNA - spleen [NX]"	"Tissue RNA - stomach 1 [NX]"	"Tissue RNA - testis [NX]"	"Tissue RNA - thalamus [NX]"	"Tissue RNA - thymus [NX]"	"Tissue RNA - thyroid gland [NX]"	"Tissue RNA - tongue [NX]"	"Tissue RNA - tonsil [NX]"	"Tissue RNA - urinary bladder [NX]"	"Tissue RNA - vagina [NX]"	"Tissue RNA - B-cells [NX]"	"Tissue RNA - dendritic cells [NX]"	"Tissue RNA - granulocytes [NX]"	"Tissue RNA - monocytes [NX]"	"Tissue RNA - NK-cells [NX]"	"Tissue RNA - T-cells [NX]"	"Tissue RNA - total PBMC [NX]"	"Cell RNA - A-431 [NX]"	"Cell RNA - A549 [NX]"	"Cell RNA - AF22 [NX]"	"Cell RNA - AN3-CA [NX]"	"Cell RNA - ASC diff [NX]"	"Cell RNA - ASC TERT1 [NX]"	"Cell RNA - BEWO [NX]"	"Cell RNA - BJ [NX]"	"Cell RNA - BJ hTERT+ [NX]"	"Cell RNA - BJ hTERT+ SV40 Large T+ [NX]"	"Cell RNA - BJ hTERT+ SV40 Large T+ RasG12V [NX]"	"Cell RNA - CACO-2 [NX]"	"Cell RNA - CAPAN-2 [NX]"	"Cell RNA - Daudi [NX]"	"Cell RNA - EFO-21 [NX]"	"Cell RNA - fHDF/TERT166 [NX]"	"Cell RNA - GAMG [NX]"	"Cell RNA - HaCaT [NX]"	"Cell RNA - HAP1 [NX]"	"Cell RNA - HBEC3-KT [NX]"	"Cell RNA - HBF TERT88 [NX]"	"Cell RNA - HDLM-2 [NX]"	"Cell RNA - HEK 293 [NX]"	"Cell RNA - HEL [NX]"	"Cell RNA - HeLa [NX]"	"Cell RNA - Hep G2 [NX]"	"Cell RNA - HHSteC [NX]"	"Cell RNA - HL-60 [NX]"	"Cell RNA - HMC-1 [NX]"	"Cell RNA - HSkMC [NX]"	"Cell RNA - hTCEpi [NX]"	"Cell RNA - hTEC/SVTERT24-B [NX]"	"Cell RNA - hTERT-HME1 [NX]"	"Cell RNA - hTERT-RPE1 [NX]"	"Cell RNA - HUVEC TERT2 [NX]"	"Cell RNA - JURKAT [NX]"	"Cell RNA - K-562 [NX]"	"Cell RNA - Karpas-707 [NX]"	"Cell RNA - LHCN-M2 [NX]"	"Cell RNA - MCF7 [NX]"	"Cell RNA - MOLT-4 [NX]"	"Cell RNA - NB-4 [NX]"	"Cell RNA - NTERA-2 [NX]"	"Cell RNA - OE19 [NX]"	"Cell RNA - PC-3 [NX]"	"Cell RNA - REH [NX]"	"Cell RNA - RH-30 [NX]"	"Cell RNA - RPMI-8226 [NX]"	"Cell RNA - RPTEC TERT1 [NX]"	"Cell RNA - RT4 [NX]"	"Cell RNA - SCLC-21H [NX]"	"Cell RNA - SH-SY5Y [NX]"	"Cell RNA - SiHa [NX]"	"Cell RNA - SK-BR-3 [NX]"	"Cell RNA - SK-MEL-30 [NX]"	"Cell RNA - SuSa [NX]"	"Cell RNA - T-47d [NX]"	"Cell RNA - THP-1 [NX]"	"Cell RNA - TIME [NX]"	"Cell RNA - U-138 MG [NX]"	"Cell RNA - U-2 OS [NX]"	"Cell RNA - U-2197 [NX]"	"Cell RNA - U-251 MG [NX]"	"Cell RNA - U-266/70 [NX]"	"Cell RNA - U-266/84 [NX]"	"Cell RNA - U-698 [NX]"	"Cell RNA - U-87 MG [NX]"	"Cell RNA - U-937 [NX]"	"Cell RNA - WM-115 [NX]"	"Blood RNA - basophil [NX]"	"Blood RNA - classical monocyte [NX]"	"Blood RNA - eosinophil [NX]"	"Blood RNA - gdT-cell [NX]"	"Blood RNA - intermediate monocyte [NX]"	"Blood RNA - MAIT T-cell [NX]"	"Blood RNA - memory B-cell [NX]"	"Blood RNA - memory CD4 T-cell [NX]"	"Blood RNA - memory CD8 T-cell [NX]"	"Blood RNA - myeloid DC [NX]"	"Blood RNA - naive B-cell [NX]"	"Blood RNA - naive CD4 T-cell [NX]"	"Blood RNA - naive CD8 T-cell [NX]"	"Blood RNA - neutrophil [NX]"	"Blood RNA - NK-cell [NX]"	"Blood RNA - non-classical monocyte [NX]"	"Blood RNA - plasmacytoid DC [NX]"	"Blood RNA - T-reg [NX]"	"Blood RNA - total PBMC [NX]"	"Brain RNA - amygdala [NX]"	"Brain RNA - basal ganglia [NX]"	"Brain RNA - cerebellum [NX]"	"Brain RNA - cerebral cortex [NX]"	"Brain RNA - hippocampal formation [NX]"	"Brain RNA - hypothalamus [NX]"	"Brain RNA - midbrain [NX]"	"Brain RNA - olfactory region [NX]"	"Brain RNA - pons and medulla [NX]"	"Brain RNA - thalamus [NX]"	"Single Cell Type RNA - Alveolar cells type 1 [NX]"	"Single Cell Type RNA - Alveolar cells type 2 [NX]"	"Single Cell Type RNA - B-cells [NX]"	"Single Cell Type RNA - Basal glandular cells [NX]"	"Single Cell Type RNA - Basal keratinocytes [NX]"	"Single Cell Type RNA - Bipolar cells [NX]"	"Single Cell Type RNA - Cardiomyocytes [NX]"	"Single Cell Type RNA - Cholangiocytes [NX]"	"Single Cell Type RNA - Ciliated cells [NX]"	"Single Cell Type RNA - Club cells [NX]"	"Single Cell Type RNA - Collecting duct cells [NX]"	"Single Cell Type RNA - Cone photoreceptor cells [NX]"	"Single Cell Type RNA - Cytotrophoblasts [NX]"	"Single Cell Type RNA - Distal tubular cells [NX]"	"Single Cell Type RNA - Ductal cells [NX]"	"Single Cell Type RNA - Early spermatids [NX]"	"Single Cell Type RNA - Endothelial cells [NX]"	"Single Cell Type RNA - Enterocytes [NX]"	"Single Cell Type RNA - Erythroid cells [NX]"	"Single Cell Type RNA - Exocrine glandular cells [NX]"	"Single Cell Type RNA - Extravillous trophoblasts [NX]"	"Single Cell Type RNA - Fibroblasts [NX]"	"Single Cell Type RNA - Glandular cells [NX]"	"Single Cell Type RNA - granulocytes [NX]"	"Single Cell Type RNA - Hepatocytes [NX]"	"Single Cell Type RNA - Hofbauer cells [NX]"	"Single Cell Type RNA - Horizontal cells [NX]"	"Single Cell Type RNA - Intestinal endocrine cells [NX]"	"Single Cell Type RNA - Ito cells [NX]"	"Single Cell Type RNA - Kupffer cells [NX]"	"Single Cell Type RNA - Late spermatids [NX]"	"Single Cell Type RNA - Leydig cells [NX]"	"Single Cell Type RNA - Macrophages [NX]"	"Single Cell Type RNA - Melanocytes [NX]"	"Single Cell Type RNA - monocytes [NX]"	"Single Cell Type RNA - Mucus-secreting cells [NX]"	"Single Cell Type RNA - Muller glia cells [NX]"	"Single Cell Type RNA - Pancreatic endocrine cells [NX]"	"Single Cell Type RNA - Paneth cells [NX]"	"Single Cell Type RNA - Peritubular cells [NX]"	"Single Cell Type RNA - Proximal tubular cells [NX]"	"Single Cell Type RNA - Rod photoreceptor cells [NX]"	"Single Cell Type RNA - Sertoli cells [NX]"	"Single Cell Type RNA - Smooth muscle cells [NX]"	"Single Cell Type RNA - Spermatocytes [NX]"	"Single Cell Type RNA - Spermatogonia [NX]"	"Single Cell Type RNA - Suprabasal keratinocytes [NX]"	"Single Cell Type RNA - Syncytiotrophoblasts [NX]"	"Single Cell Type RNA - T-cells [NX]"	"Single Cell Type RNA - Undifferentiated cells [NX]"	"Single Cell Type RNA - Urothelial cells [NX]"
ALDH1L1	"10-fTHF, FTHFD"	ENSG00000144908	"Aldehyde dehydrogenase 1 family member L1"	O75891	3	126103562-126197994	"Enzymes, Plasma proteins, Predicted intracellular proteins"	"One-carbon metabolism"	Oxidoreductase		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in many"		"kidney: 48.1;liver: 148.7"	"Group enriched"	"Detected in many"	6	"Hepatocytes: 554.3;Proximal tubular cells: 175.8"	"Cancer enhanced"	"Detected in many"		"liver cancer: 40.4"	"Low region specificity"	"Detected in all"			"Not detected"	"Not detected"			"Not detected"	"Not detected"			"Cell line enhanced"	"Detected in some"		"ASC diff: 10.9;Hep G2: 23.9;Karpas-707: 24.7;RPMI-8226: 12.9;RT4: 66.0;U-266/70: 13.6"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA036900, HPA050139"	Enhanced	Supported	Supported	Cytosol		No	No		640000	Cytosol		"HPA036900: AB_10672273, HPA050139: AB_2681031"	"unprognostic (5.93e-2)"	"unprognostic (1.22e-1)"	"unprognostic (9.12e-2)"	"unprognostic (2.68e-1)"	"unprognostic (1.10e-1)"	"unprognostic (1.10e-1)"	"unprognostic (7.12e-2)"	"unprognostic (1.29e-1)"	"unprognostic (3.05e-2)"	"unprognostic (4.73e-2)"	"unprognostic (3.05e-3)"	"unprognostic (8.40e-2)"	"prognostic favorable (2.42e-8)"	"unprognostic (3.60e-1)"	"unprognostic (1.47e-1)"	"unprognostic (7.03e-3)"	"unprognostic (7.93e-2)"	28.9	12.1	13.7	1.8	17.1	1.2	6.0	8.6	10.9	7.8	4.9	5.7	2.3	1.1	1.9	2.2	3.6	3.4	1.9	8.1	8.9	5.3	48.1	148.7	1.3	1.2	9.2	10.1	11.3	10.2	1.4	0.9	1.1	10.8	3.3	3.3	5.1	34.1	4.1	30.7	1.5	1.3	2.4	7.7	1.1	1.9	4.9	6.2	0.0	1.7	6.2	2.8	11.0	3.1	0.1	0.8	0.8	0.2	0.2	0.4	0.0	0.4	0.0	0.0	0.0	10.9	0.0	0.1	0.1	0.4	0.1	0.2	0.0	0.9	0.7	3.2	0.0	0.6	0.1	0.2	0.4	0.2	0.0	0.0	0.0	0.1	23.9	3.2	3.1	0.0	0.0	0.2	0.0	0.0	0.1	0.0	0.0	0.0	24.7	0.4	0.0	0.0	0.0	0.1	0.3	0.0	0.0	0.0	12.9	0.3	66.0	0.1	0.1	0.3	3.2	0.0	0.2	0.0	0.0	0.1	0.4	1.9	0.0	0.0	13.6	4.2	0.1	0.0	0.0	0.0	0.8	0.2	0.0	0.1	0.2	0.0	0.0	0.2	0.0	0.2	0.1	0.4	0.2	0.2	0.2	0.0	0.8	0.1	0.0	13.7	17.1	8.6	10.9	8.9	5.3	9.2	10.1	10.8	6.2	0.0	5.9	4.5	44.7	0.1	0.2	14.9	22.9	10.7	64.8	12.2	0.0	0.0	61.3	2.2	18.0	2.7	2.3	0.0	4.8	0.1	0.8	8.1	25.6	554.3	0.1	0.0	1.2	12.3	15.3	25.4	24.5	2.6	3.3	0.0	9.1	35.7	1.9	0.0	21.2	175.8	1.0	6.5	1.0	1.1	1.2	0.0	0.1	7.0	2.2	48.0
ALDH1L2	"FLJ38508, mtFDH"	ENSG00000136010	"Aldehyde dehydrogenase 1 family member L2"	Q3SY69	12	105019784-105084577	"Enzymes, Predicted intracellular proteins"	"One-carbon metabolism"	Oxidoreductase		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Group enriched"	"Detected in many"	7	"pancreas: 48.9;salivary gland: 31.6"	"Cell type enhanced"	"Detected in many"	6	"Exocrine glandular cells: 8.3;monocytes: 6.4;Pancreatic endocrine cells: 5.6;Peritubular cells: 6.3"	"Low cancer specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Cell type enriched"	"Detected in single"	5	"plasmacytoid DC: 1.3"	"Lineage enriched"	"Detected in single"	6	"dendritic cells: 1.3"	"Cell line enhanced"	"Detected in many"		"ASC diff: 23.0;ASC TERT1: 31.5;fHDF/TERT166: 35.7;HHSteC: 20.3;HSkMC: 25.5"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA039481, HPA059282"	Approved		Enhanced	Mitochondria		No	No			Mitochondria		"HPA039481: AB_10795465, HPA059282: AB_2732633"	"unprognostic (5.99e-2)"	"unprognostic (1.42e-1)"	"unprognostic (1.10e-1)"	"unprognostic (1.36e-3)"	"unprognostic (1.76e-1)"	"unprognostic (8.86e-2)"	"unprognostic (1.75e-1)"	"unprognostic (2.92e-1)"	"unprognostic (5.74e-2)"	"unprognostic (1.51e-1)"	"unprognostic (1.01e-1)"	"unprognostic (1.61e-1)"	"unprognostic (8.19e-8)"	"unprognostic (3.21e-3)"	"unprognostic (1.33e-1)"	"unprognostic (2.53e-3)"	"unprognostic (2.52e-5)"	4.2	1.2	3.2	2.7	1.9	0.7	2.7	5.3	2.7	5.5	2.2	0.9	3.3	2.4	2.9	3.2	1.5	2.6	2.7	2.9	1.6	2.0	0.7	0.4	2.7	2.0	2.0	2.1	1.0	48.9	0.7	2.8	1.1	2.5	3.6	2.3	4.8	31.6	4.5	1.0	1.5	1.3	5.4	5.3	1.2	3.7	0.8	1.3	0.0	2.2	1.4	3.0	3.9	2.2	0.2	1.3	0.0	0.1	0.0	0.1	0.1	4.4	0.4	0.2	9.6	23.0	31.5	0.5	14.2	9.2	1.8	4.9	0.5	0.0	0.0	0.6	35.7	0.0	0.0	0.0	0.3	2.3	0.0	0.1	0.2	0.0	1.1	20.3	1.8	0.0	25.5	1.1	4.8	9.1	0.0	1.0	0.0	0.7	12.9	3.7	0.0	0.0	0.1	0.6	0.0	0.1	0.0	0.0	1.3	0.0	0.0	3.3	1.6	0.0	2.9	7.2	0.1	2.1	15.2	0.1	1.4	1.4	0.0	0.7	16.0	4.2	0.0	5.8	6.6	0.4	0.0	0.1	0.0	0.0	0.0	0.0	0.2	0.0	0.0	0.2	0.0	0.1	0.0	0.0	0.0	0.0	1.3	0.0	0.1	3.2	1.9	5.3	2.4	1.6	2.0	2.0	2.1	2.5	1.3	0.0	1.1	0.0	0.1	0.5	1.5	1.2	0.0	0.0	0.0	0.0	0.0	0.1	0.0	0.3	3.7	0.1	0.0	0.0	8.3	0.3	4.3	0.3	0.0	0.0	0.4	4.8	0.0	1.8	0.3	4.5	3.4	1.1	5.0	6.4	0.0	1.2	5.6	0.0	6.3	0.0	0.5	0.0	3.1	0.4	0.0	0.5	0.2	0.0	0.0	0.1
AMT	"GCST, NKH"	ENSG00000145020	Aminomethyltransferase	P48728	3	49416775-49422753	"Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins"		"Aminotransferase, Transferase"	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in many"			"Cell type enhanced"	"Detected in many"	4	"Hepatocytes: 37.3"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"		"NK-cell: 8.9"	"Low lineage specificity"	"Detected in many"			"Cell line enhanced"	"Detected in some"		"BEWO: 10.4;Hep G2: 29.9;NTERA-2: 5.4;SH-SY5Y: 7.9;SuSa: 7.3"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA005566	Supported		Supported	Nucleoplasm,Mitochondria		NA	NA			Mitochondria	Nucleoplasm	"HPA005566: AB_1844811"	"unprognostic (2.10e-2)"	"unprognostic (1.65e-2)"	"unprognostic (1.82e-1)"	"unprognostic (9.14e-3)"	"unprognostic (4.04e-1)"	"unprognostic (1.11e-2)"	"unprognostic (2.81e-1)"	"unprognostic (2.17e-3)"	"unprognostic (1.94e-1)"	"unprognostic (3.29e-1)"	"unprognostic (7.17e-3)"	"unprognostic (1.88e-1)"	"prognostic favorable (3.90e-8)"	"unprognostic (4.40e-1)"	"unprognostic (1.91e-1)"	"unprognostic (3.60e-1)"	"unprognostic (1.98e-3)"	4.7	10.9	6.6	8.0	8.8	6.0	6.6	16.7	10.4	8.4	10.0	7.4	21.3	10.9	9.2	11.1	3.4	9.7	13.0	16.6	7.4	2.0	21.4	41.2	5.6	2.3	7.6	8.3	14.5	18.5	16.3	10.4	2.5	10.7	9.1	10.1	12.2	9.8	20.0	3.8	5.4	11.0	7.1	5.8	7.9	8.1	2.6	7.4	1.7	8.7	0.4	1.8	6.2	8.1	0.7	5.4	4.7	3.2	8.9	1.6	2.3	0.1	0.5	0.7	0.1	0.4	0.0	10.4	0.0	0.2	0.1	0.2	0.3	0.2	0.0	0.1	0.2	0.0	0.2	0.1	0.4	0.1	0.2	0.2	0.0	0.3	29.9	1.1	0.0	0.1	0.3	0.7	0.0	0.4	1.1	0.1	0.2	0.0	0.0	0.1	0.3	0.2	0.2	5.4	0.0	0.1	0.0	0.1	0.2	0.7	0.2	0.0	7.9	0.1	0.0	0.6	7.3	0.0	0.1	0.0	0.0	0.0	0.0	0.1	0.6	0.1	0.0	0.0	0.1	0.0	0.0	3.2	4.7	0.0	1.9	0.1	0.6	0.0	0.0	5.4	0.7	1.6	1.5	0.3	8.9	0.7	0.5	0.0	2.3	6.6	8.8	16.7	10.4	7.4	2.0	7.6	8.3	10.7	7.4	3.0	11.6	3.7	11.4	2.5	17.2	18.3	17.8	6.7	7.9	0.0	19.6	22.7	0.0	0.7	1.7	2.7	19.7	0.0	0.6	6.5	4.7	10.1	7.0	37.3	4.4	7.9	12.2	3.1	2.7	1.6	9.8	3.5	5.0	0.0	16.2	21.5	0.5	14.0	6.0	0.7	17.7	6.5	4.3	1.4	0.4	2.4	8.6	5.7	31.1	8.6
DHFR		ENSG00000228716	"Dihydrofolate reductase"	P00374	5	80626228-80654983	"Cancer-related genes, Disease related genes, Enzymes, FDA approved drug targets, Predicted intracellular proteins"	"Methotrexate resistance, One-carbon metabolism"	"Oxidoreductase, RNA-binding"	"Cancer-related genes, Disease mutation, FDA approved drug targets"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"	10	"Erythroid cells: 163.5;Spermatocytes: 92.4"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"											"CAB037129, HPA051465"	Uncertain		Approved	Mitochondria		NA	Yes			Mitochondria		"CAB037129: AB_439683, HPA051465: AB_2681494"	"unprognostic (1.44e-2)"	"unprognostic (1.03e-2)"	"unprognostic (2.24e-3)"	"unprognostic (2.91e-3)"	"unprognostic (3.27e-1)"	"unprognostic (1.32e-1)"	"unprognostic (2.83e-2)"	"unprognostic (2.35e-2)"	"unprognostic (2.02e-2)"	"unprognostic (4.19e-3)"	"unprognostic (1.83e-2)"	"unprognostic (2.55e-1)"	"unprognostic (1.15e-2)"	"unprognostic (1.82e-2)"	"unprognostic (2.49e-1)"	"unprognostic (1.57e-1)"	"unprognostic (1.09e-1)"	17.7	6.1	16.0	11.6	13.9	28.3	10.9	10.2	14.0	7.5	12.6	18.1	11.7	14.5	5.9	9.0	9.8	4.7	6.9	9.7	17.3	14.4	13.1	35.5	8.6	23.2	18.9	9.4	7.5	4.9	9.6	7.2	8.5	13.0	5.9	15.5	8.6	8.0	8.4	10.4	5.9	14.5	7.3	25.3	9.1	7.4	10.5	11.5	13.4	9.2	2.3	22.8	7.9	6.1	2.4	3.3	3.5	2.6	2.1	4.0	2.1	19.8	13.8	35.1	25.9	6.6	7.0	12.9	15.9	12.2	27.8	32.1	13.1	24.0	40.4	7.0	9.2	22.7	14.0	45.1	20.5	45.0	17.9	27.8	19.3	23.0	12.1	1.4	22.5	8.6	4.8	2.1	24.9	2.8	4.7	13.4	29.7	21.7	31.1	28.1	19.9	55.4	9.1	17.7	9.9	8.1	36.0	68.9	40.0	16.0	12.7	28.7	20.0	22.5	10.5	11.4	18.6	20.8	22.3	8.0	8.8	13.4	24.6	30.4	14.6	29.2	43.7	19.7	45.8	22.6	0.8	1.2	1.1	2.3	2.6	1.1	2.1	2.7	3.2	1.9	2.4	2.1	2.7	3.5	2.1	1.7	3.3	4.0	2.1	16.0	13.9	10.2	14.0	17.3	14.4	18.9	9.4	13.0	11.5	6.0	9.4	21.6	5.3	6.2	3.7	13.2	7.6	8.1	6.8	14.0	2.0	13.0	8.3	6.6	4.3	3.6	20.0	163.5	3.3	35.4	9.5	2.1	2.3	41.2	36.1	3.2	4.7	9.2	13.2	4.6	13.0	8.3	0.0	2.8	11.1	10.0	4.3	5.8	15.2	33.5	3.4	12.9	9.0	92.4	48.0	4.8	11.1	10.1	21.0	3.7
DHFR2	"DHFRL1, DHFRP4, FLJ16119"	ENSG00000178700	"Dihydrofolate reductase 2"	Q86XF0	3	94047836-94063389	"Enzymes, Predicted intracellular proteins"	"One-carbon metabolism"	Oxidoreductase		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"	11	"Alveolar cells type 1: 11.9;Ciliated cells: 16.0"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Cell line enriched"	"Detected in many"	13	"hTERT-RPE1: 61.0"									HPA051465	Uncertain		Approved	Mitochondria		NA	NA			Mitochondria		"HPA051465: AB_2681494"	"unprognostic (1.16e-1)"	"unprognostic (1.15e-1)"	"unprognostic (1.10e-2)"	"unprognostic (3.50e-2)"	"unprognostic (2.07e-1)"	"unprognostic (1.38e-1)"	"unprognostic (5.92e-2)"	"unprognostic (1.33e-1)"	"unprognostic (1.12e-1)"	"unprognostic (4.62e-2)"	"unprognostic (2.95e-1)"	"unprognostic (1.52e-1)"	"prognostic favorable (2.30e-6)"	"unprognostic (1.63e-1)"	"unprognostic (1.79e-1)"	"unprognostic (1.13e-1)"	"unprognostic (2.96e-2)"	6.6	8.0	9.7	5.2	10.9	2.2	7.7	5.2	13.2	9.8	6.3	15.2	2.8	5.8	11.7	9.9	5.3	9.4	7.6	5.1	9.8	8.1	10.6	9.3	7.1	7.3	10.2	6.9	15.3	10.8	15.4	13.1	4.5	12.2	9.5	6.7	6.2	6.6	8.9	2.8	5.8	10.1	9.0	12.6	9.4	6.6	8.2	8.6	16.9	10.3	4.8	6.4	7.3	6.2	5.0	4.1	3.8	3.3	2.8	7.3	2.5	1.3	2.1	1.6	1.6	2.3	2.9	0.6	2.1	2.3	1.1	1.2	0.4	2.2	0.9	1.4	1.1	1.4	1.9	1.2	1.5	1.7	3.0	0.7	1.1	1.0	1.2	2.3	0.7	1.3	2.9	2.0	1.2	1.6	61.0	1.1	4.6	0.5	2.1	1.4	1.7	3.9	0.4	1.3	3.9	2.6	1.0	2.1	1.5	1.5	0.7	2.0	2.1	3.1	0.8	3.5	1.3	2.1	1.1	1.7	1.7	2.9	0.7	0.8	1.6	1.5	1.3	1.7	2.0	2.3	3.6	2.2	3.8	3.8	3.2	7.3	3.8	5.1	6.1	1.4	5.0	6.9	6.2	3.5	2.8	3.3	4.1	6.1	2.5	9.7	10.9	5.2	13.2	9.8	8.1	10.2	6.9	12.2	8.6	11.9	4.3	0.0	0.0	0.0	0.0	0.0	0.0	16.0	3.4	3.5	0.0	2.0	3.3	4.8	0.0	0.0	0.0	0.0	4.8	1.5	0.0	0.0	2.3	0.0	2.8	0.0	0.0	0.0	0.0	0.0	0.0	1.1	0.0	4.6	0.0	0.0	4.6	0.0	0.0	5.2	0.0	0.0	0.0	0.0	0.0	0.0	0.7	0.0	0.0	0.0
DLD	"DLDH, GCSL, LAD"	ENSG00000091140	"Dihydrolipoamide dehydrogenase"	P09622	7	107890970-107931730	"Citric acid cycle related proteins, Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins"		Oxidoreductase	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"	6	"Cardiomyocytes: 284.8"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA044849	Supported		Approved	Nucleoplasm,Mitochondria		NA	NA		16000000	Mitochondria	Nucleoplasm	"HPA044849: AB_2679111"	"unprognostic (2.01e-3)"	"unprognostic (2.26e-1)"	"unprognostic (1.27e-2)"	"unprognostic (9.27e-2)"	"unprognostic (5.01e-3)"	"unprognostic (9.27e-2)"	"unprognostic (2.48e-1)"	"unprognostic (2.83e-2)"	"unprognostic (1.19e-1)"	"unprognostic (3.95e-2)"	"unprognostic (9.43e-2)"	"unprognostic (7.35e-2)"	"prognostic favorable (7.58e-9)"	"unprognostic (4.08e-2)"	"unprognostic (1.88e-1)"	"unprognostic (4.45e-3)"	"unprognostic (1.18e-1)"	25.7	37.9	14.5	12.7	25.4	12.0	15.2	16.6	27.2	13.2	28.0	10.6	12.2	20.9	13.6	9.6	25.6	11.6	12.7	69.1	16.4	14.4	40.7	37.9	11.0	13.0	16.7	20.1	15.1	14.8	24.6	22.4	15.4	29.3	14.7	26.8	12.8	19.4	14.4	71.5	13.8	29.5	23.7	10.6	17.4	23.0	10.6	10.7	18.7	17.0	31.8	16.9	20.1	11.7	13.5	30.4	45.8	37.8	22.9	19.4	20.2	40.1	32.6	18.1	31.1	26.0	23.0	20.5	23.1	19.5	26.9	20.9	38.0	22.6	39.3	39.9	24.5	44.0	26.7	36.3	32.6	40.7	26.2	21.6	27.6	43.2	27.1	20.0	45.4	28.5	26.2	23.7	28.6	15.6	17.1	32.3	33.0	68.9	29.3	29.2	45.1	37.1	32.9	21.5	48.5	23.7	26.8	29.0	53.3	36.8	60.0	22.5	23.8	37.8	64.0	34.0	37.6	24.4	38.9	20.4	29.8	24.4	57.9	35.1	22.2	42.3	26.4	28.0	48.5	30.7	36.5	22.3	45.8	17.5	28.2	18.5	13.5	17.7	17.3	30.4	12.3	18.7	19.4	14.0	22.9	37.8	10.5	16.8	20.2	14.5	25.4	16.6	27.2	16.4	14.4	16.7	20.1	29.3	10.7	26.8	16.5	23.1	30.6	27.8	45.9	284.8	61.1	37.5	18.2	75.0	21.6	94.8	192.3	59.5	3.8	30.0	47.9	46.7	49.3	49.9	26.3	23.6	26.5	77.8	61.0	20.6	29.4	27.6	36.8	5.6	21.6	34.1	35.4	65.9	39.3	31.3	37.7	56.1	39.6	134.4	33.4	25.8	43.4	41.2	52.4	28.2	90.6	27.7	64.6	28.5
FPGS		ENSG00000136877	"Folylpolyglutamate synthase"	Q05932	9	127794597-127814327	"Enzymes, Predicted intracellular proteins"	"One-carbon metabolism"	Ligase		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA050488	Approved				"Intracellular and membrane"	NA	NA					"HPA050488: AB_2681143"	"unprognostic (6.37e-2)"	"unprognostic (1.06e-1)"	"unprognostic (1.02e-1)"	"prognostic favorable (9.08e-4)"	"unprognostic (1.25e-1)"	"unprognostic (2.67e-1)"	"unprognostic (1.00e-1)"	"unprognostic (1.89e-1)"	"unprognostic (6.25e-2)"	"unprognostic (2.63e-1)"	"unprognostic (1.16e-1)"	"unprognostic (6.97e-2)"	"unprognostic (1.76e-1)"	"unprognostic (8.54e-3)"	"unprognostic (2.61e-1)"	"unprognostic (1.58e-1)"	"unprognostic (1.55e-2)"	18.2	25.0	6.0	17.4	7.1	14.8	18.9	7.9	6.9	13.9	16.6	9.2	16.6	9.3	16.8	19.2	12.2	17.1	20.0	19.2	6.1	5.9	12.5	44.0	14.9	25.6	8.1	6.6	41.3	24.0	6.6	8.9	6.7	7.7	12.8	6.3	9.9	12.3	18.9	30.4	7.9	10.3	12.6	5.4	17.6	12.4	10.1	7.7	13.6	11.1	15.2	16.0	14.7	9.2	15.5	19.9	1.0	11.8	20.4	21.1	10.2	13.6	9.5	5.4	11.7	8.5	9.3	16.9	10.9	12.9	13.9	10.6	9.8	22.3	17.0	14.2	14.7	9.3	25.8	6.7	14.8	4.5	18.5	8.8	13.2	11.9	12.0	20.3	24.3	11.3	13.0	8.5	13.2	17.7	11.7	16.5	16.0	14.8	11.0	14.2	17.3	21.1	18.1	15.8	15.0	29.1	44.0	9.1	29.5	20.0	11.0	8.2	14.0	31.3	15.3	2.1	2.3	9.2	10.3	24.9	7.2	10.3	20.9	21.6	12.3	5.2	13.6	15.7	11.3	10.5	0.1	7.8	1.0	21.1	11.8	18.9	12.2	12.6	18.2	15.6	15.5	10.4	13.7	0.4	20.4	11.6	19.9	13.1	10.2	6.0	7.1	7.9	6.9	6.1	5.9	8.1	6.6	7.7	7.7	20.8	29.1	20.1	17.5	9.3	5.4	18.0	33.1	6.7	19.4	8.7	13.7	13.4	10.0	43.0	3.1	16.3	13.6	0.0	46.4	18.3	16.9	18.0	30.1	61.4	27.0	4.8	22.0	16.5	12.7	2.1	17.5	18.2	8.5	71.3	10.9	6.3	54.2	10.5	6.7	15.9	6.5	12.9	16.5	6.5	16.6	7.8	12.4	22.3	22.2	28.6
FTCD		ENSG00000160282	"Formimidoyltransferase cyclodeaminase"	O95954	21	46136262-46155567	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"	"Histidine metabolism"	"Lyase, Multifunctional enzyme, Transferase"	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in some"	5	"liver: 126.8"	"Cell type enhanced"	"Detected in many"	16	"Hepatocytes: 338.0;Late spermatids: 92.6;Proximal tubular cells: 322.0"	"Cancer enriched"	"Detected in some"	8	"liver cancer: 87.3"	"Low region specificity"	"Detected in single"			"Cell type enhanced"	"Detected in single"		"T-reg: 2.5"	"Lineage enriched"	"Detected in single"	25	"T-cells: 2.5"	"Cell line enriched"	"Detected in some"	29	"Hep G2: 45.4"									"HPA020073, HPA030928, HPA030929, HPA036114"	Enhanced		Approved	"Plasma membrane,Cytosol"		No	NA		580000	Cytosol	"Plasma membrane"	"HPA020073: AB_1849005, HPA030928: AB_2673664, HPA030929: AB_2673665, HPA036114: AB_2674947"	"unprognostic (1.71e-1)"	"unprognostic (2.27e-1)"	"unprognostic (4.62e-5)"	"unprognostic (2.90e-2)"	"unprognostic (1.13e-1)"	"unprognostic (2.96e-1)"	"prognostic favorable (1.70e-4)"	"unprognostic (1.85e-1)"	"unprognostic (2.67e-1)"	"unprognostic (1.99e-1)"	"prognostic favorable (6.78e-5)"	"unprognostic (1.80e-1)"	"prognostic favorable (5.78e-4)"	"unprognostic (3.80e-2)"	"unprognostic (3.60e-1)"	"unprognostic (9.37e-2)"	"unprognostic (2.10e-1)"	0.2	0.0	0.6	0.2	1.6	0.0	0.2	0.2	0.7	0.2	0.3	0.2	0.2	0.3	0.2	2.0	0.2	0.0	0.2	0.2	0.5	0.4	25.9	126.8	0.2	0.2	0.4	0.2	0.2	1.0	0.0	0.2	0.2	0.2	0.3	0.0	0.2	0.2	0.2	0.2	0.0	0.4	0.2	0.2	0.2	0.1	1.5	0.2	0.2	0.2	0.2	0.2	0.2	0.2	0.0	0.0	0.0	0.0	0.0	2.5	0.1	0.0	0.0	0.0	0.0	0.2	0.0	0.0	0.0	0.0	0.1	0.0	1.5	0.0	0.1	0.1	0.0	0.4	0.0	0.0	0.0	0.0	0.0	0.3	0.3	0.0	45.4	0.0	0.3	0.2	0.0	0.0	0.1	0.0	0.0	0.0	0.1	0.3	0.0	0.0	0.3	0.0	0.0	1.0	0.0	0.0	0.1	0.1	0.0	0.1	0.0	0.4	0.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.1	0.2	0.2	0.0	0.1	0.0	0.0	0.2	0.1	0.0	0.0	0.0	0.0	0.9	0.0	0.0	0.0	0.5	0.5	0.0	0.0	0.5	0.7	0.0	0.0	0.0	0.0	2.5	0.1	0.6	1.6	0.2	0.7	0.5	0.4	0.4	0.2	0.2	0.2	0.0	0.0	24.9	0.0	0.1	1.0	1.0	68.8	0.0	0.0	8.7	0.0	0.0	39.7	0.0	75.4	0.6	0.0	0.0	0.0	0.0	0.8	0.5	0.0	338.0	0.1	3.2	0.0	22.7	22.3	92.6	2.8	0.0	0.0	0.0	0.0	0.1	0.0	0.0	2.5	322.0	0.4	0.0	0.1	10.7	12.2	0.4	0.0	6.9	0.0	0.0
GCSH		ENSG00000140905	"Glycine cleavage system protein H"	P23434	16	81081938-81096425	"Disease related genes, Plasma proteins, Predicted intracellular proteins"				"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"liver: 55.9"	"Cell type enhanced"	"Detected in many"	13	"Cytotrophoblasts: 501.6;Extravillous trophoblasts: 1237.6;Proximal tubular cells: 489.6"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"											"HPA041368, HPA057079"	Supported		Approved	Vesicles	"Intracellular and membrane"	NA	NA			Vesicles		"HPA041368: AB_10804001, HPA057079: "	"unprognostic (4.09e-2)"	"unprognostic (2.98e-2)"	"unprognostic (2.29e-1)"	"unprognostic (2.47e-3)"	"unprognostic (2.55e-3)"	"unprognostic (4.87e-2)"	"unprognostic (1.38e-1)"	"unprognostic (1.67e-1)"	"unprognostic (2.75e-1)"	"unprognostic (1.96e-2)"	"unprognostic (6.92e-2)"	"unprognostic (2.80e-2)"	"prognostic favorable (6.26e-6)"	"unprognostic (1.12e-2)"	"unprognostic (2.59e-1)"	"unprognostic (6.31e-2)"	"unprognostic (6.47e-2)"	10.9	10.0	28.9	3.7	26.8	3.0	11.4	8.1	21.8	9.9	6.4	15.0	14.2	3.8	9.4	35.9	6.0	10.4	6.3	11.7	23.5	20.6	37.3	55.9	4.0	5.8	30.8	15.8	8.9	10.2	19.4	7.2	12.9	18.7	9.9	7.0	10.4	9.4	9.3	18.1	4.3	3.1	6.9	27.6	2.6	5.2	3.5	17.9	6.7	48.7	5.9	4.8	6.6	4.9	4.4	12.2	2.8	2.6	7.9	7.3	2.9	18.1	8.0	25.3	11.0	12.4	9.6	51.7	10.6	7.9	12.9	6.3	10.7	17.0	4.8	9.6	4.6	9.8	9.3	19.3	10.7	21.6	1.3	25.2	6.2	10.7	33.0	14.1	20.0	7.2	9.8	14.4	8.0	16.5	4.0	6.5	13.5	24.0	1.0	12.8	19.2	13.0	40.6	33.4	14.6	16.8	20.4	13.3	7.2	29.2	16.7	13.1	13.6	15.2	9.9	20.0	20.4	14.5	9.6	5.7	8.4	14.7	13.3	10.9	4.1	8.7	29.0	5.6	12.0	6.7	2.8	1.7	1.7	3.4	2.6	5.7	4.4	3.3	4.9	4.5	3.3	5.8	7.3	2.2	7.9	2.0	12.2	2.6	2.9	28.9	26.8	8.1	21.8	23.5	20.6	30.8	15.8	18.7	17.9	3.0	5.1	31.8	74.7	25.8	44.4	11.8	33.1	20.1	13.6	76.8	35.3	501.6	250.4	57.2	25.7	29.8	9.8	0.0	37.0	1237.6	66.3	92.3	36.8	317.5	102.2	36.5	25.3	31.3	17.6	15.2	130.3	25.7	81.0	24.4	29.9	130.3	38.6	14.0	132.6	489.6	42.3	32.3	58.7	20.0	68.6	23.7	191.3	21.0	48.6	56.2
GGH		ENSG00000137563	"Gamma-glutamyl hydrolase"	Q92820	8	63015079-63039171	"Enzymes, Plasma proteins, Predicted intracellular proteins"		Hydrolase		"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"kidney: 42.5;liver: 59.5"	"Cell type enhanced"	"Detected in many"	10	"Cytotrophoblasts: 501.9;Early spermatids: 395.4;Syncytiotrophoblasts: 631.0"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Cell type enriched"	"Detected in many"	4	"plasmacytoid DC: 18.2"	"Lineage enriched"	"Detected in all"	4	"dendritic cells: 18.2"	"Low cell line specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB019296, HPA025226"	Approved				"Intracellular and membrane"	NA	NA		1400000000			"CAB019296: , HPA025226: AB_1849645"	"unprognostic (9.29e-2)"	"unprognostic (1.22e-1)"	"unprognostic (5.48e-3)"	"prognostic unfavorable (3.99e-7)"	"unprognostic (5.57e-2)"	"unprognostic (1.08e-1)"	"unprognostic (1.14e-1)"	"prognostic unfavorable (1.65e-4)"	"unprognostic (1.95e-2)"	"unprognostic (1.60e-1)"	"unprognostic (2.11e-2)"	"unprognostic (1.32e-1)"	"unprognostic (1.69e-2)"	"unprognostic (9.62e-3)"	"unprognostic (1.50e-1)"	"unprognostic (2.36e-1)"	"unprognostic (6.50e-2)"	3.5	3.6	7.4	4.7	8.6	12.3	11.8	15.5	9.9	3.5	17.6	1.5	1.0	3.7	2.6	3.7	11.0	1.6	2.8	5.9	7.9	7.6	42.5	59.5	3.5	5.0	4.7	7.0	1.9	4.2	1.0	1.6	17.7	14.8	1.9	26.4	2.2	6.5	1.8	1.7	11.1	3.6	4.2	7.6	3.7	3.2	14.0	3.8	5.2	1.4	14.5	7.6	3.9	6.6	4.1	18.2	2.1	1.9	2.9	1.4	1.4	20.0	19.3	19.8	3.0	19.5	8.2	14.6	12.4	21.2	19.7	28.5	27.0	35.6	13.7	3.5	15.3	33.2	16.8	19.6	20.7	29.2	27.8	14.8	22.5	10.4	18.2	3.7	10.5	13.5	6.0	5.9	19.8	9.5	12.5	23.7	14.0	12.0	50.3	36.8	11.3	5.1	10.5	9.3	44.9	18.3	15.3	19.3	18.4	15.2	7.0	7.9	13.6	18.0	19.7	18.8	19.1	21.7	11.7	12.5	21.2	23.8	20.3	22.2	23.6	24.0	16.1	32.7	0.0	37.3	0.0	1.9	2.1	1.1	1.1	0.5	4.1	1.3	1.3	0.6	1.9	1.0	1.3	1.8	2.9	1.2	18.2	1.4	1.4	7.4	8.6	15.5	9.9	7.9	7.6	4.7	7.0	14.8	3.8	14.9	8.2	22.6	16.2	26.9	1.7	1.6	17.8	14.7	14.8	21.0	0.0	501.9	31.5	20.1	395.4	8.3	17.2	46.7	6.4	234.3	29.8	8.2	10.4	171.3	65.1	0.0	12.7	15.4	18.7	97.7	5.5	15.0	23.6	54.1	74.6	20.3	6.2	8.6	7.8	214.6	1.1	25.8	10.8	73.7	141.6	37.6	631.0	10.1	104.6	12.5
GLDC	"GCSP, NKH"	ENSG00000178445	"Glycine decarboxylase"	P23378	9	6532464-6645783	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"		Oxidoreductase	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Group enriched"	"Detected in many"	4	"kidney: 22.3;liver: 40.3;placenta: 10.6"	"Cell type enhanced"	"Detected in many"	17	"Cytotrophoblasts: 59.4;Extravillous trophoblasts: 35.6;Hepatocytes: 126.2;Syncytiotrophoblasts: 38.4"	"Cancer enhanced"	"Detected in many"		"testis cancer: 41.4"	"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in some"			"Low lineage specificity"	"Detected in many"			"Cell line enhanced"	"Detected in some"		"BEWO: 66.8;CACO-2: 15.9;HMC-1: 14.5;RPTEC TERT1: 27.7"	"Low region specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"HPA002318, HPA052887"	Enhanced		Supported	Nucleoplasm,Mitochondria		NA	NA		570000	Mitochondria	Nucleoplasm	"HPA002318: AB_1849700, HPA052887: AB_2681980"	"unprognostic (6.73e-2)"	"unprognostic (1.19e-1)"	"unprognostic (6.50e-2)"	"prognostic unfavorable (5.24e-5)"	"unprognostic (1.50e-1)"	"unprognostic (7.87e-2)"	"unprognostic (1.81e-1)"	"unprognostic (1.50e-1)"	"unprognostic (2.40e-1)"	"unprognostic (1.74e-1)"	"unprognostic (2.47e-2)"	"unprognostic (2.69e-1)"	"prognostic favorable (3.50e-4)"	"unprognostic (1.65e-2)"	"unprognostic (1.27e-1)"	"unprognostic (5.62e-3)"	"unprognostic (1.17e-2)"	0.2	0.3	3.9	1.0	3.4	0.4	0.4	3.1	5.6	0.3	0.8	1.6	0.0	0.7	0.4	4.2	1.4	0.6	0.6	0.1	2.9	2.2	22.3	40.3	0.8	1.1	1.9	2.9	0.3	0.1	0.0	1.7	10.6	2.1	0.4	0.3	3.2	0.9	0.8	0.9	1.5	0.6	0.1	1.9	0.8	0.8	1.1	1.8	0.0	2.6	0.0	1.9	0.8	0.0	2.9	0.7	2.3	0.5	0.8	0.6	1.1	0.1	1.3	0.6	7.2	0.0	0.1	66.8	0.0	0.0	0.0	0.0	15.9	0.1	0.1	1.6	0.0	0.2	0.1	0.0	0.1	0.0	0.3	3.8	0.0	0.0	10.6	0.0	0.0	14.5	0.0	0.0	0.5	0.0	0.2	2.7	1.2	0.0	0.1	0.3	0.3	0.2	0.0	7.8	1.2	1.2	0.3	0.0	0.1	27.7	0.3	6.4	3.3	0.0	6.2	0.0	4.1	1.4	0.0	0.9	0.1	0.2	0.8	0.3	0.3	9.2	0.0	0.2	0.7	1.5	1.5	0.5	0.5	0.5	0.3	0.5	2.9	0.6	0.4	0.1	0.9	0.4	0.5	2.3	0.8	0.5	0.7	0.2	1.1	3.9	3.4	3.1	5.6	2.9	2.2	1.9	2.9	2.1	1.8	0.0	0.0	4.3	0.0	0.0	0.3	0.6	7.6	0.0	0.0	29.6	0.0	59.4	5.0	0.0	8.8	0.0	0.0	0.0	0.2	35.6	0.0	0.0	0.0	126.2	6.1	0.0	0.0	3.1	2.1	9.0	0.3	0.0	0.0	0.0	0.0	8.6	0.1	0.0	0.0	29.3	0.2	0.0	0.3	4.4	5.0	0.0	38.4	0.5	0.0	0.0
GPHN	KIAA1385	ENSG00000171723	Gephyrin	Q9NQX3	14	66507407-67181803	"Cancer-related genes, Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"	"Molybdenum cofactor biosynthesis"	"Multifunctional enzyme, Transferase"	"Cancer-related genes, Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"	5	"Cone photoreceptor cells: 49.1;Hepatocytes: 42.9;Horizontal cells: 41.3"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in many"			"Low cell line specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA003116, CAB004419, HPA024694"	Enhanced		Uncertain	"Cytoplasmic bodies"		NA	NA			"Cytoplasmic bodies"		"CAB004419: AB_627670, HPA003116: AB_1078963, HPA024694: AB_1849616"	"unprognostic (8.37e-2)"	"unprognostic (2.53e-2)"	"unprognostic (2.42e-1)"	"unprognostic (1.20e-1)"	"unprognostic (5.14e-2)"	"unprognostic (4.89e-3)"	"unprognostic (8.29e-2)"	"unprognostic (1.41e-2)"	"unprognostic (1.42e-1)"	"unprognostic (2.23e-1)"	"unprognostic (2.49e-2)"	"unprognostic (8.54e-2)"	"prognostic favorable (5.25e-12)"	"unprognostic (9.81e-2)"	"unprognostic (2.27e-1)"	"unprognostic (7.50e-2)"	"prognostic unfavorable (4.61e-5)"	13.0	12.4	26.1	10.9	31.1	5.2	17.1	40.9	31.2	11.0	18.2	9.3	15.6	11.1	12.3	20.8	8.6	7.5	8.2	11.9	26.4	22.9	34.5	49.0	14.1	7.3	18.3	11.5	7.2	22.9	17.4	24.5	5.8	13.9	11.1	13.2	7.4	10.8	21.3	23.4	10.7	10.8	11.6	16.4	5.6	13.5	7.8	16.2	3.1	12.2	10.0	6.8	7.4	15.1	3.1	3.0	0.5	2.5	2.3	6.2	1.5	22.2	4.4	7.8	8.5	9.2	7.8	5.0	6.3	3.1	6.5	6.5	1.3	10.0	0.0	1.1	3.1	3.3	7.9	7.8	12.3	8.6	6.8	8.4	6.6	6.3	13.6	4.8	3.7	9.8	6.7	7.3	1.8	7.2	2.7	7.5	8.3	4.5	8.4	3.6	11.9	6.5	13.9	3.3	16.8	10.1	0.0	15.0	6.4	10.5	4.4	13.8	5.4	4.3	18.9	6.9	2.2	10.1	6.4	2.8	6.5	14.5	6.4	6.5	11.2	4.8	0.1	5.1	0.5	6.3	0.0	1.3	0.5	3.9	2.5	6.2	2.4	4.9	2.9	1.9	3.1	3.5	3.3	0.0	2.3	1.9	3.0	5.3	1.5	26.1	31.1	40.9	27.0	26.4	22.9	18.3	11.5	13.9	16.2	6.0	9.6	5.4	8.3	4.1	33.5	10.9	7.6	1.4	13.6	1.8	49.1	2.8	11.6	4.1	2.5	9.0	5.1	0.0	4.7	2.1	4.1	6.7	0.0	42.9	3.1	41.3	5.8	19.0	7.6	3.6	10.3	2.7	1.7	0.0	11.9	10.4	2.9	7.0	5.3	14.9	34.2	0.0	6.2	10.9	8.9	5.1	1.7	4.9	8.9	6.0
MOCS1	MOCOD	ENSG00000124615	"Molybdenum cofactor synthesis 1"	Q9NZB8	6	39899578-39934551	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"	"Molybdenum cofactor biosynthesis"	Lyase	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in many"			"Cell type enhanced"	"Detected in many"	14	"Cytotrophoblasts: 23.5;Hepatocytes: 33.6;Sertoli cells: 77.6"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Cell type enhanced"	"Detected in some"		"naive CD4 T-cell: 2.9;naive CD8 T-cell: 2.5"	"Group enriched"	"Detected in many"	9	"NK-cells: 1.5;T-cells: 2.9"	"Cell line enhanced"	"Detected in many"		"CACO-2: 23.6;JURKAT: 30.1"	"Low region specificity"	"Detected in all"							"HPA045783, HPA058177, HPA075505"	Uncertain		Enhanced	Cytosol		NA	NA			Cytosol		"HPA045783: AB_10960058, HPA058177: AB_2683629, HPA075505: AB_2686751"	"unprognostic (1.22e-1)"	"prognostic unfavorable (1.07e-5)"	"unprognostic (3.26e-2)"	"unprognostic (1.44e-1)"	"unprognostic (9.03e-2)"	"unprognostic (1.99e-1)"	"unprognostic (2.61e-2)"	"unprognostic (4.85e-2)"	"unprognostic (3.14e-2)"	"unprognostic (1.08e-1)"	"prognostic favorable (6.07e-5)"	"unprognostic (5.34e-3)"	"unprognostic (1.21e-1)"	"unprognostic (3.97e-3)"	"unprognostic (2.78e-1)"	"unprognostic (2.93e-1)"	"unprognostic (6.21e-2)"	26.6	9.6	4.6	5.3	7.9	0.2	27.1	5.9	8.7	6.4	17.5	10.5	5.0	15.4	10.1	8.7	6.9	7.9	8.0	18.0	6.2	2.3	17.5	34.9	19.6	9.2	9.5	6.2	9.0	10.9	4.5	6.3	30.2	7.0	6.7	5.2	11.2	5.9	7.6	19.9	7.1	13.1	8.9	7.1	3.5	6.5	4.0	7.6	0.2	15.4	5.9	3.1	9.7	7.7	0.0	0.1	0.0	0.2	1.5	2.9	0.8	0.0	1.2	4.4	7.1	12.1	4.6	9.0	4.9	8.9	7.0	6.4	23.6	0.1	0.0	5.1	4.8	4.5	0.3	5.3	5.9	5.4	0.0	4.9	0.0	0.0	7.5	7.7	0.0	1.9	8.1	2.2	4.9	2.6	4.3	6.0	30.1	4.8	0.4	7.1	3.0	9.2	0.0	4.1	0.0	2.6	0.0	3.4	0.7	4.3	4.6	3.6	4.7	0.0	2.9	4.1	3.7	3.1	0.8	9.3	7.0	6.1	4.6	2.5	0.0	0.9	0.0	0.8	0.0	2.5	0.0	0.1	0.0	1.2	0.0	0.0	0.0	0.6	0.5	0.1	0.0	2.9	2.5	0.0	1.5	0.2	0.0	0.0	0.8	4.6	7.9	5.9	8.7	6.2	2.3	9.5	6.2	7.0	7.6	6.0	1.0	0.0	0.5	0.6	0.8	10.1	7.6	0.0	0.0	8.7	11.8	23.5	5.0	3.4	0.6	2.8	6.4	0.0	3.7	1.2	2.9	0.2	1.1	33.6	2.5	3.2	0.0	2.5	2.8	0.6	3.4	0.0	1.7	0.0	2.9	4.2	1.1	4.8	2.8	12.2	2.2	77.6	15.6	1.4	1.5	1.0	5.1	0.0	4.1	0.3
MOCS2	MOCO1	ENSG00000164172	"Molybdenum cofactor synthesis 2"	"O96007, O96033"	5	53095679-53110063	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"	"Molybdenum cofactor biosynthesis"	Transferase	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"	11	"Distal tubular cells: 485.7;Proximal tubular cells: 194.9"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA037679, HPA037680"	Approved		Supported	"Nucleoplasm,Nuclear speckles,Cytosol"		NA	NA			Cytosol	"Nucleoplasm, Nuclear speckles"	"HPA037679: AB_2675604, HPA037680: AB_10673635"	"unprognostic (3.27e-1)"	"unprognostic (3.11e-2)"	"unprognostic (2.82e-1)"	"unprognostic (8.37e-3)"	"unprognostic (2.12e-1)"	"unprognostic (3.48e-2)"	"unprognostic (1.60e-2)"	"unprognostic (1.33e-1)"	"unprognostic (6.66e-2)"	"unprognostic (7.59e-2)"	"unprognostic (2.41e-3)"	"unprognostic (1.85e-1)"	"prognostic favorable (3.68e-6)"	"unprognostic (1.04e-1)"	"unprognostic (1.04e-2)"	"unprognostic (2.04e-1)"	"unprognostic (5.86e-2)"	18.1	34.6	41.5	9.8	38.0	4.0	19.6	21.7	41.8	16.0	17.1	20.7	10.4	17.6	14.8	28.2	17.0	12.9	15.9	39.9	36.7	32.1	49.7	52.0	13.1	11.4	30.0	22.4	21.2	18.4	30.4	23.3	16.2	28.7	18.6	14.9	17.2	21.2	20.8	38.3	8.9	17.6	16.1	27.1	10.7	16.6	11.0	20.0	8.2	31.5	19.4	11.2	16.9	15.4	16.9	12.5	6.3	10.9	17.3	25.8	12.9	20.2	16.6	12.0	28.7	24.6	22.7	15.2	24.9	26.2	22.2	26.4	22.6	15.2	20.7	37.5	19.6	34.4	12.3	24.0	25.5	35.0	5.2	23.4	15.9	16.3	20.4	25.3	17.2	12.0	18.1	12.8	25.2	22.5	22.0	23.8	26.7	15.4	11.3	37.0	30.0	18.5	9.8	10.6	8.7	34.6	9.4	25.8	18.8	38.4	15.4	8.9	10.3	18.1	14.8	18.6	15.9	28.6	4.4	15.2	21.3	22.1	18.9	32.0	13.3	19.7	23.4	30.5	4.9	32.9	5.2	9.2	6.3	16.9	10.9	20.2	16.5	19.0	19.2	12.5	16.9	25.8	22.2	1.7	17.3	9.8	11.4	18.3	12.9	41.5	38.0	21.7	41.8	36.7	32.1	30.0	22.4	28.7	20.0	50.6	20.6	25.2	32.7	11.8	27.0	111.0	66.2	36.1	19.4	66.3	25.5	82.4	485.7	34.6	5.6	32.8	17.8	0.0	38.2	28.9	48.8	44.5	9.3	99.9	36.5	6.4	25.3	19.0	25.0	10.1	46.9	27.4	21.9	7.2	17.9	36.8	23.4	19.3	64.7	194.9	18.1	32.3	50.3	40.7	54.7	13.7	27.0	26.1	22.9	30.2
MTHFD1	"MTHFC, MTHFD"	ENSG00000100714	"Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1"	P11586	14	64388031-64463457	"Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins, Predicted membrane proteins"	"Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis"	"Hydrolase, Ligase, Multifunctional enzyme, Oxidoreductase"	"Disease mutation"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enriched"	"Detected in all"	5	"liver: 121.6"	"Cell type enhanced"	"Detected in many"	8	"Hepatocytes: 125.3"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in many"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA000704, HPA001290, HPA015006, HPA050052"	Approved		Enhanced	Cytosol		NA	Yes		250000	Cytosol		"HPA000704: AB_1079424, HPA001290: AB_1854177, HPA015006: AB_1854178, HPA050052: AB_2680998"	"unprognostic (3.58e-2)"	"unprognostic (5.50e-3)"	"unprognostic (1.24e-1)"	"unprognostic (2.46e-2)"	"unprognostic (1.37e-1)"	"unprognostic (7.01e-2)"	"unprognostic (8.85e-3)"	"unprognostic (7.62e-3)"	"unprognostic (1.28e-1)"	"unprognostic (2.29e-2)"	"prognostic unfavorable (6.96e-4)"	"unprognostic (1.84e-1)"	"prognostic favorable (5.93e-5)"	"unprognostic (2.45e-2)"	"unprognostic (1.75e-1)"	"unprognostic (7.30e-2)"	"unprognostic (2.29e-2)"	18.9	9.0	8.1	8.4	18.1	9.7	12.2	5.7	15.9	7.1	9.3	9.0	4.0	7.5	8.5	6.9	12.0	6.7	6.4	10.6	8.4	6.5	20.5	121.6	6.8	9.2	8.0	10.4	10.1	13.4	13.1	5.6	5.6	10.0	5.5	11.4	9.3	11.6	5.6	26.5	7.6	7.3	8.8	6.9	8.3	7.9	2.3	7.4	15.6	8.6	14.0	12.5	8.7	7.3	21.1	12.8	0.5	13.2	12.8	14.9	8.4	72.5	41.3	15.7	34.2	16.9	13.8	25.5	28.5	19.6	37.0	36.7	40.1	33.4	30.5	13.5	16.9	18.6	35.7	48.4	28.3	43.3	30.3	31.9	37.8	41.4	30.4	12.5	29.0	20.6	10.7	9.2	33.0	17.9	15.3	23.0	30.9	28.1	25.1	28.0	60.2	46.7	17.0	28.7	46.2	43.8	37.3	54.6	27.6	27.8	42.5	34.0	13.2	47.6	25.9	14.3	15.3	40.3	14.7	14.1	27.9	48.4	25.7	34.1	16.8	20.6	53.8	25.6	33.5	31.6	0.2	8.2	0.1	8.1	13.2	10.9	21.1	9.0	9.9	12.8	11.6	7.6	10.1	0.5	12.8	10.3	3.2	14.9	8.4	8.1	18.1	5.7	15.9	8.4	6.5	8.0	10.4	10.0	7.4	17.9	26.3	11.5	9.9	12.2	0.0	38.1	17.8	12.0	20.5	15.7	0.0	20.0	34.9	15.4	0.9	9.9	5.2	0.0	9.0	24.2	10.6	8.3	49.7	125.3	21.6	0.0	2.9	7.4	11.3	0.9	12.0	10.9	13.5	14.4	11.9	0.0	10.8	2.9	12.4	49.9	0.0	19.4	18.6	0.9	7.5	9.4	8.2	20.0	21.3	9.9
MTHFD1L	"DKFZP586G1517, FLJ21145, FTHFSDC1"	ENSG00000120254	"Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like"	Q6UB35	6	150865549-151101887	"Enzymes, Predicted intracellular proteins, Predicted membrane proteins"	"One-carbon metabolism"	Ligase		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"	11	"Extravillous trophoblasts: 107.1;Syncytiotrophoblasts: 61.6;Urothelial cells: 39.1"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in many"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA015006, HPA029040, HPA029041, HPA050052, HPA074911"	Approved		Enhanced	Mitochondria		NA	NA			Mitochondria		"HPA015006: AB_1854178, HPA029040: AB_2672879, HPA029041: AB_2672880, HPA050052: AB_2680998, HPA074911: AB_2686723"	"unprognostic (3.66e-2)"	"prognostic unfavorable (1.68e-5)"	"unprognostic (1.02e-1)"	"prognostic unfavorable (7.28e-4)"	"unprognostic (3.25e-1)"	"prognostic unfavorable (5.10e-4)"	"prognostic unfavorable (8.33e-5)"	"unprognostic (6.35e-3)"	"unprognostic (2.45e-1)"	"unprognostic (1.44e-1)"	"unprognostic (1.02e-1)"	"unprognostic (1.32e-1)"	"unprognostic (1.11e-2)"	"unprognostic (2.93e-2)"	"unprognostic (3.51e-1)"	"unprognostic (2.91e-1)"	"prognostic unfavorable (8.69e-5)"	10.4	10.6	8.0	12.1	8.1	12.2	7.1	32.4	10.5	6.5	6.2	7.8	10.2	3.4	8.5	7.2	6.4	8.0	7.3	10.7	7.5	7.9	9.5	6.9	17.1	11.0	12.3	7.6	22.2	13.7	7.1	9.1	15.5	8.5	5.0	9.1	12.7	3.4	10.5	2.5	5.7	4.7	10.9	10.2	8.7	5.6	13.6	6.6	6.7	12.2	5.0	11.4	8.7	5.1	1.1	3.0	0.2	0.8	1.0	5.0	0.6	12.0	10.5	13.7	33.7	3.6	12.6	33.5	19.0	20.8	19.1	23.6	21.1	11.3	44.5	12.7	29.0	11.3	12.9	21.9	18.5	23.8	18.3	19.9	18.5	18.7	19.3	22.6	33.8	3.0	14.9	23.7	18.5	33.8	17.2	31.9	24.9	43.9	23.3	19.6	25.4	16.5	7.0	14.0	12.1	9.7	19.8	10.2	19.8	12.9	5.9	13.7	10.2	25.1	11.1	15.5	13.0	3.5	23.7	24.2	12.8	28.1	28.4	26.9	19.4	18.0	46.4	21.3	31.6	16.5	0.2	0.7	0.0	0.8	0.8	1.3	0.8	1.9	2.1	3.0	1.1	1.8	1.9	0.0	1.0	0.8	1.5	5.0	0.6	8.0	8.1	32.4	9.5	7.5	7.9	12.3	7.6	8.5	6.6	0.0	1.7	10.7	5.1	5.8	0.0	2.4	2.5	4.0	2.3	14.0	0.0	18.7	6.6	10.4	19.2	7.1	0.9	0.0	15.4	107.1	15.4	4.1	0.0	1.0	21.7	0.0	1.2	3.7	2.4	3.4	0.6	10.1	33.7	1.0	2.5	0.0	15.0	0.8	7.4	12.2	0.0	0.0	6.1	0.5	6.4	3.0	61.6	3.2	3.5	39.1
MTHFD2		ENSG00000065911	"Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2, methenyltetrahydrofolate cyclohydrolase"	P13995	2	74198562-74217565	"Enzymes, Predicted intracellular proteins"	"One-carbon metabolism"	"Hydrolase, Multifunctional enzyme, Oxidoreductase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"	6	"monocytes: 263.3;Smooth muscle cells: 264.7"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"CAB003684, HPA049657"	Approved		Supported	Mitochondria	"Intracellular and membrane"	NA	NA			Mitochondria		"CAB003684: AB_425867, HPA049657: AB_2680842"	"unprognostic (1.82e-3)"	"unprognostic (4.60e-2)"	"unprognostic (8.12e-2)"	"prognostic unfavorable (2.07e-5)"	"prognostic favorable (1.01e-4)"	"unprognostic (3.10e-3)"	"unprognostic (2.24e-3)"	"unprognostic (4.75e-3)"	"unprognostic (2.64e-2)"	"unprognostic (3.96e-2)"	"unprognostic (3.76e-3)"	"unprognostic (3.57e-3)"	"prognostic unfavorable (1.11e-16)"	"unprognostic (3.66e-2)"	"unprognostic (6.52e-2)"	"unprognostic (9.07e-2)"	"unprognostic (2.34e-3)"	26.2	5.7	5.8	21.6	14.1	12.1	21.9	3.0	8.0	15.1	12.4	5.9	12.6	10.1	15.8	8.7	14.1	17.5	10.5	12.1	10.0	8.2	12.0	3.4	15.9	21.0	19.0	1.5	20.6	39.7	1.5	15.6	8.2	16.1	12.7	15.3	3.0	32.9	12.0	39.4	8.6	9.2	21.0	25.6	26.3	15.3	11.9	11.8	8.4	11.4	16.7	23.5	20.3	41.8	4.8	11.4	13.6	19.7	10.7	12.7	6.3	18.6	6.9	7.8	26.6	8.6	9.7	20.6	23.5	15.9	13.8	19.6	15.9	7.9	39.4	6.3	12.7	15.4	6.6	25.9	13.8	26.1	21.2	10.8	38.0	3.9	15.4	35.2	27.6	25.4	20.0	44.1	17.2	74.8	7.1	9.2	63.6	17.5	57.4	13.5	11.7	17.3	34.2	17.0	27.2	11.5	19.3	21.9	34.7	7.9	5.5	20.4	14.9	8.1	24.4	55.1	5.9	20.9	38.4	4.0	4.3	34.7	9.8	26.3	47.5	21.0	32.0	11.9	33.9	12.2	13.6	8.1	9.6	3.3	19.7	4.8	4.8	6.0	3.6	11.4	3.0	4.3	3.3	1.1	10.7	19.1	5.0	12.7	6.3	5.8	14.1	3.0	8.0	10.0	8.2	19.0	1.5	16.1	11.8	14.9	26.5	62.1	28.1	79.3	0.0	8.2	7.6	2.7	13.6	1.8	0.0	20.5	3.3	54.8	3.2	18.0	6.9	93.5	92.6	49.1	52.6	48.5	53.0	0.6	64.6	0.0	18.3	13.5	55.9	2.9	21.0	92.7	67.4	263.3	33.2	0.0	75.9	5.8	19.8	1.4	0.0	135.8	264.7	30.1	55.8	65.2	11.7	30.5	21.6	55.0
MTHFD2L	MGC72244	ENSG00000163738	"Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 2 like"	Q9H903	4	74114174-74303099	"Enzymes, Predicted intracellular proteins"	"Amino-acid biosynthesis, Histidine biosynthesis, Methionine biosynthesis, One-carbon metabolism, Purine biosynthesis"	"Hydrolase, Multifunctional enzyme, Oxidoreductase"		"Evidence at protein level"	"Evidence at protein level"	"Evidence at transcript level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Cell type enhanced"	"Detected in many"	4	"Hepatocytes: 105.4"	"Low cancer specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in many"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			HPA035434	Uncertain					NA	NA					"HPA035434: AB_10601038"	"unprognostic (2.01e-1)"	"unprognostic (2.19e-1)"	"unprognostic (2.03e-1)"	"unprognostic (2.32e-2)"	"unprognostic (1.52e-2)"	"unprognostic (4.09e-2)"	"unprognostic (2.67e-2)"	"unprognostic (7.73e-3)"	"unprognostic (1.42e-4)"	"unprognostic (3.45e-3)"	"unprognostic (4.23e-2)"	"unprognostic (5.07e-2)"	"unprognostic (1.44e-1)"	"unprognostic (3.16e-2)"	"unprognostic (1.19e-1)"	"unprognostic (3.00e-1)"	"unprognostic (1.81e-3)"	5.4	11.7	10.2	6.0	8.8	5.2	10.3	6.9	8.5	4.5	5.6	5.9	8.2	5.3	5.6	10.9	6.3	5.0	5.6	17.7	9.3	10.7	6.9	16.2	7.0	5.8	10.5	4.1	5.8	13.6	6.1	7.4	5.8	6.6	5.3	4.0	4.8	4.9	6.2	9.3	4.2	5.6	4.9	11.0	5.1	4.1	2.9	7.3	14.8	10.5	5.0	3.8	3.8	8.4	3.9	3.9	1.4	6.5	2.5	2.7	2.5	2.6	2.8	3.9	3.6	1.4	2.1	0.9	3.3	2.6	2.2	2.4	2.1	2.5	2.9	4.5	1.5	1.6	1.7	3.2	2.1	3.3	2.9	1.9	3.5	1.9	2.5	2.5	5.5	0.7	1.5	5.1	3.3	7.9	4.1	4.6	6.5	6.2	3.6	2.7	2.6	10.2	7.9	1.2	4.3	3.1	10.4	2.7	4.8	14.2	1.3	3.7	8.1	1.8	2.8	3.3	4.5	1.5	3.9	4.7	2.5	3.8	4.8	5.4	3.6	4.6	8.5	15.6	1.3	3.8	0.4	2.1	0.9	0.7	2.0	0.7	3.9	0.6	0.9	3.3	1.5	2.1	2.2	1.4	2.5	6.5	3.9	2.7	2.5	10.2	8.8	6.9	7.3	9.3	10.7	10.5	4.1	6.6	7.3	20.8	15.8	16.8	49.0	14.7	0.0	21.3	25.5	22.7	21.6	47.1	0.0	16.4	71.3	20.8	53.1	14.3	16.8	46.7	16.6	6.3	12.2	87.5	10.3	105.4	21.6	0.0	35.7	18.4	22.7	16.4	11.8	19.6	15.1	11.8	31.5	0.0	16.0	17.5	8.1	35.8	0.0	25.8	18.4	6.5	10.0	19.7	10.3	12.2	33.8	58.9
MTHFR		ENSG00000177000	"Methylenetetrahydrofolate reductase"	P42898	1	11785723-11806920	"Disease related genes, Enzymes, Potential drug targets, Predicted intracellular proteins"		"Allosteric enzyme, Oxidoreductase"	"Disease mutation, Schizophrenia"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Low tissue specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in all"			"Low lineage specificity"	"Detected in all"			"Cell line enhanced"	"Detected in all"		"K-562: 27.4"	"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA063389, HPA076180, HPA077255"	Enhanced		Approved	"Cell Junctions"		NA	NA			"Cell Junctions"		"HPA063389: AB_2685001, HPA076180: , HPA077255: "	"unprognostic (3.25e-2)"	"unprognostic (8.19e-2)"	"unprognostic (4.48e-2)"	"unprognostic (2.11e-2)"	"unprognostic (1.34e-1)"	"prognostic favorable (3.97e-5)"	"prognostic unfavorable (1.19e-4)"	"unprognostic (1.75e-2)"	"unprognostic (2.85e-1)"	"unprognostic (8.69e-2)"	"prognostic favorable (4.81e-5)"	"unprognostic (3.10e-1)"	"prognostic favorable (2.12e-4)"	"unprognostic (2.35e-3)"	"unprognostic (2.94e-1)"	"unprognostic (4.14e-2)"	"unprognostic (1.80e-2)"	11.7	11.0	8.9	10.3	12.4	24.5	9.7	15.3	15.8	9.0	10.4	13.5	8.3	10.7	10.4	54.5	11.3	12.7	10.9	23.4	9.2	8.6	12.0	12.4	16.2	13.3	9.9	10.7	28.8	11.2	6.7	17.5	6.6	10.7	10.2	9.1	14.1	7.3	7.2	15.3	13.2	13.6	10.9	7.4	18.3	13.6	10.6	10.9	10.2	15.8	9.8	11.7	10.4	17.9	4.9	3.2	4.7	7.4	3.4	4.7	2.3	1.3	5.9	6.8	7.8	6.8	10.5	1.1	4.2	8.8	4.0	3.5	5.4	8.7	11.4	2.3	4.3	9.3	2.6	4.8	4.0	1.7	5.4	4.4	8.4	7.4	1.5	9.1	4.6	10.9	9.2	4.0	3.0	3.3	6.6	6.2	10.8	27.4	7.5	4.1	1.8	5.0	2.2	2.3	5.9	2.1	5.2	3.7	12.6	6.4	7.2	6.8	11.6	5.2	5.1	8.2	4.3	8.1	7.2	5.5	4.0	3.3	4.7	1.0	4.2	5.7	21.3	4.9	10.6	3.6	1.1	3.8	1.9	4.7	7.4	1.8	3.0	1.6	2.5	3.2	4.9	2.4	2.7	4.7	3.4	6.9	1.5	1.0	2.3	8.9	12.4	15.3	15.8	9.2	8.6	9.9	10.7	10.7	10.9	23.8	50.3	12.3	6.7	7.4	0.0	35.5	10.2	5.3	10.3	26.2	0.0	4.1	1.7	7.7	13.8	16.2	32.7	46.7	22.0	2.7	16.0	9.3	8.1	19.5	18.8	0.0	11.6	38.6	38.0	28.3	17.0	26.2	11.8	10.8	15.4	0.0	15.7	17.8	8.5	14.3	0.0	19.4	24.7	6.0	4.7	8.2	2.4	8.7	16.5	8.1
MTHFS	HsT19268	ENSG00000136371	"Methenyltetrahydrofolate synthetase"	P49914	15	79833585-79897379	"Enzymes, Predicted intracellular proteins"		Ligase	"Disease mutation, Epilepsy"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"blood: 88.7;liver: 120.9"	"Cell type enhanced"	"Detected in many"	7	"Hepatocytes: 163.6;monocytes: 231.8;Proximal tubular cells: 140.3;Syncytiotrophoblasts: 212.2"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Cell type enhanced"	"Detected in all"		"neutrophil: 88.7"	"Group enriched"	"Detected in all"	5	"granulocytes: 88.7;monocytes: 25.4"	"Low cell line specificity"	"Detected in many"											"HPA008067, HPA054177"	Approved		Supported	Cytosol		NA	NA			Cytosol		"HPA008067: AB_1078882, HPA054177: AB_2682405"	"unprognostic (4.57e-2)"	"unprognostic (9.76e-2)"	"unprognostic (6.11e-2)"	"unprognostic (1.82e-1)"	"prognostic unfavorable (8.52e-4)"	"unprognostic (9.13e-3)"	"prognostic favorable (1.29e-6)"	"unprognostic (1.34e-2)"	"unprognostic (1.03e-1)"	"unprognostic (6.18e-3)"	"unprognostic (2.91e-2)"	"unprognostic (2.76e-1)"	"prognostic favorable (2.04e-4)"	"unprognostic (1.36e-1)"	"unprognostic (2.85e-1)"	"unprognostic (7.60e-2)"	"unprognostic (2.90e-1)"	10.0	6.6	4.5	7.6	4.4	2.5	5.7	3.9	2.8	4.4	12.4	3.7	6.8	8.3	4.3	6.2	4.5	4.0	7.9	5.2	4.1	5.0	27.9	120.9	6.4	5.4	5.5	1.7	3.3	18.8	11.4	9.4	13.9	3.9	8.6	3.7	6.5	10.6	7.6	6.0	1.9	18.3	4.4	6.1	7.6	6.3	5.9	3.3	5.3	12.0	3.1	5.7	4.0	9.9	9.7	9.3	88.7	25.4	12.4	12.6	13.8	10.9	27.7	2.5	1.4	9.8	8.3	11.2	7.7	10.1	13.5	10.3	21.5	21.6	13.8	23.4	9.5	12.1	17.7	23.6	7.5	10.3	14.3	15.7	11.8	16.1	25.5	17.0	5.5	0.4	12.5	22.1	5.6	14.1	12.6	5.0	12.2	26.1	11.3	10.7	23.6	8.5	23.0	11.8	34.2	10.4	9.3	13.6	20.9	24.6	20.6	6.8	3.2	21.4	12.8	28.2	12.5	16.4	10.2	3.3	5.2	11.0	2.4	5.1	5.7	18.4	13.9	2.6	21.8	4.0	9.8	16.6	43.5	7.7	19.0	9.9	9.7	10.8	9.0	9.3	8.7	12.6	9.7	88.7	12.4	25.4	7.0	11.2	13.8	4.5	4.4	3.9	2.8	4.1	5.0	5.5	1.7	3.9	3.3	17.9	35.3	18.8	8.6	9.5	0.0	0.6	40.8	25.4	18.2	21.0	0.0	57.2	54.7	50.9	1.1	8.4	11.9	0.0	65.9	31.6	13.1	11.4	8.1	163.6	41.2	0.0	16.9	16.5	21.5	1.7	12.7	29.7	20.3	231.8	22.7	0.0	65.8	29.8	14.9	140.3	0.0	12.9	5.1	7.5	7.3	7.0	212.2	35.2	30.5	7.4
QDPR	"DHPR, PKU2, SDR33C1"	ENSG00000151552	"Quinoid dihydropteridine reductase"	P09417	4	17460261-17512234	"Disease related genes, Enzymes, Plasma proteins, Potential drug targets, Predicted intracellular proteins"	"Tetrahydrobiopterin biosynthesis"	Oxidoreductase	"Disease mutation, Phenylketonuria"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Evidence at protein level"	"Tissue enhanced"	"Detected in all"		"brain: 114.1;liver: 64.8"	"Cell type enhanced"	"Detected in many"	7	"Hepatocytes: 298.8;Muller glia cells: 301.8;Proximal tubular cells: 369.1"	"Low cancer specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low cell type specificity"	"Detected in many"			"Low lineage specificity"	"Detected in all"			"Low cell line specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"Low region specificity"	"Detected in all"			"HPA058951, HPA065649"	Enhanced		Approved	Mitochondria		NA	NA		1800000	Mitochondria		"HPA058951: AB_2683861, HPA065649: AB_2685526"	"unprognostic (1.30e-2)"	"unprognostic (4.29e-1)"	"unprognostic (8.27e-2)"	"unprognostic (2.52e-1)"	"unprognostic (1.21e-1)"	"unprognostic (1.20e-1)"	"unprognostic (3.29e-3)"	"unprognostic (3.80e-3)"	"unprognostic (1.19e-1)"	"unprognostic (1.45e-1)"	"unprognostic (6.82e-3)"	"unprognostic (2.07e-1)"	"prognostic favorable (7.84e-6)"	"unprognostic (1.58e-1)"	"unprognostic (2.60e-1)"	"unprognostic (9.01e-2)"	"unprognostic (3.19e-1)"	22.5	25.9	67.8	3.4	111.9	4.4	7.4	16.0	54.1	5.7	7.5	56.3	2.6	9.1	5.5	12.5	5.2	6.4	6.3	15.0	80.7	58.2	36.1	64.8	8.0	3.7	114.1	36.7	6.7	10.3	13.7	6.2	4.1	82.5	10.3	5.9	2.6	12.4	7.5	34.2	4.6	8.1	6.4	93.6	4.8	9.1	4.1	94.7	0.7	7.7	2.8	4.4	4.5	2.6	7.5	42.5	1.0	21.9	9.9	15.0	12.3	11.6	22.8	9.0	12.5	21.9	11.1	15.9	16.6	7.0	15.5	13.6	18.2	15.4	4.3	10.7	9.2	17.3	6.6	12.8	18.8	9.7	13.1	2.6	11.8	11.8	43.0	13.2	15.3	1.1	13.7	11.9	9.7	13.4	8.3	7.8	11.0	12.6	9.9	16.6	6.0	22.8	24.6	15.3	11.0	15.4	9.5	6.9	17.2	16.0	6.4	17.1	21.8	11.0	1.8	47.2	10.3	5.0	5.9	13.5	9.0	16.1	8.9	13.2	15.4	24.0	30.2	18.0	13.5	14.9	0.0	14.4	1.0	12.3	21.9	11.1	7.5	13.3	12.8	18.0	6.2	15.0	12.9	0.4	9.9	16.3	42.5	6.9	12.3	67.8	111.9	16.0	54.1	80.7	58.2	114.1	36.7	82.5	94.7	26.8	26.9	18.2	16.6	17.7	34.9	59.2	38.2	4.0	14.8	36.6	7.9	65.3	92.9	37.2	0.8	17.8	14.2	0.0	20.5	28.8	26.3	26.4	25.3	298.8	69.8	77.9	167.4	25.8	34.9	3.3	21.0	26.9	145.1	20.8	22.6	301.8	17.0	7.0	35.7	369.1	26.6	25.8	26.4	3.3	60.7	14.1	15.3	16.7	36.6	11.1