News ArticlesAltered plasma protein profiles in genetic FTDIn a study published in Molecular Neurodegeneration an international group of scientists including researchers from KTH have used a multiplex plasma profiling assay and a well-described genetic frontotemporal dementia (FTD) cohort collected within the GENFI study to explore potential plasma biomarkers that could reflect the pathology of this disease...Read more The roles of vaccine-induced SARS-CoV-2 NAbs and T cells in protection and diseaseIn a study published in Molecular Therapy researchers from KTH among others have generated several different DNA vaccines selectively activating neutralizing antibodies (Nabs) and/or T cells and used them in different animal models to study their individual roles in the protection against severe SARS-CoV-2...Read more A multi-omics strategy to discover and validate missing proteins in the ovaryIn a publication in Journal of Proteome Research transcriptomics and spatial proteomics were used to investigate and validate the expression of so-called missing proteins in the human ovary...Read more The role of trypsin in bottom-up proteomics moving towards clinical applicationThe impact of different trypsins on commonly used bottom-up proteomics workflows were investigated across a range of sample types in a publication in Analytical Chemistry. Besides the type of trypsin, different protease concentrations, sample matrices, instrument acquisition techniques, and protease storage times were investigated...Read more A proteomics strategy to assess the reliability of biomarkers for Duchenne muscular dystrophyIn a publication in Clinical Proteomics a novel orthogonal strategy based on affinity proteomics and mass spectrometry was used for analytical validation of biomarkers in longitudinally collected serum samples from Duchenne muscular dystrophy (DMD) patients...Read more |