A new program was launched to generate a resource comprising most of the secreted proteins in humans. The genes coding for the proteins predicted to be secreted were constructed with synthetic biology and used for mammalian bioproduction using Chinese hamster ovary (CHO) cells. The program was initiated by a collaboration involving the Wallenberg Foundation, the Novo Nordisk Foundation, and the pharmaceutical company AstraZeneca.

Key publication

• Tegel H et al., High throughput generation of a resource of the human secretome in mammalian cells. N Biotechnol. (2020)
  PubMed: 32502629 DOI: 10.1016/j.nbt.2020.05.002

Other selected publications

• Uhlén M et al., The human secretome. Sci Signal. (2019)
  PubMed: 31772123 DOI: 10.1126/scisignal.aaz0274

• Jennbacken K et al., Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells. Int J Mol Sci. (2019)
  PubMed: 31801200 DOI: 10.3390/ijms20236037