Expression of FAM153B in cancer - Summary

GENERAL INFORMATIONⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	FAM153B
Gene descriptionⁱ Full gene name according to HGNC.	Family with sequence similarity 153 member B
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	6

HUMAN PROTEIN ATLAS INFORMATIONⁱ

RNA categoryⁱ

Consensus (human tissue):	Tissue enhanced (brain, ovary, testis) Detected in many
HPA (cell line):	Cell line enriched (U-2 OS) Detected in some
TCGA (cancer tissue):	Not detected Not detected

Protein evidenceⁱ

Evidence at transcript level

Protein expression
normal tissueⁱ

Estimation of protein expression could not be performed. View primary data.

IMMUNOHISTOCHEMISTRY DATA RELIABILITY
Data reliability descriptionⁱ Standardized explanatory sentences with additional information required for full understanding of the protein expression profile, based on knowledge-based and secretome-based annotation.	RNA-based expert annotation gave inconclusive results. Pending external verification. Caution, targets protein from more than one gene.
Reliability score - normal tissuesⁱ A reliability score is manually set for all genes and indicates the level of reliability of the analyzed protein expression pattern based on available RNA-seq data, protein/gene characterization data and immunohistochemical data from one or several antibodies with non-overlapping epitopes. The reliability score is based on the 44 normal tissues analyzed, and if there is available data from more than one antibody, the staining patterns of all antibodies are taken into consideration during evaluation. The reliability score is divided into Enhanced, Supported, Approved, or Uncertain, and is displayed on both Tissue Atlas and Pathology Atlas. Read more	Uncertain
Antibodiesⁱ Antibodies used for this assay. Click on an antibody for more information.	HPA042585 , HPA044022 , HPA046691 , HPA052337 , HPA055498
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PROGNOSTIC SUMMARYⁱ

Gene product is not prognostic

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RNA EXPRESSION OVERVIEWⁱ RNA expression overview shows RNA-seq data from The Cancer Genome Atlas (TCGA).
TCGA datasetⁱ RNA-seq data in 17 cancer types are reported as median FPKM (number Fragments Per Kilobase of exon per Million reads), generated by the The Cancer Genome Atlas (TCGA). RNA cancer tissue category is calculated based on mRNA expression levels across all 17 cancer tissues and include: cancer tissue enriched, cancer group enriched, cancer tissue enhanced, expressed in all, mixed and not detected. Normal distribution across the dataset is visualized with box plots, shown as median and 25th and 75th percentiles. Points are displayed as outliers if they are above or below 1.5 times the interquartile range. To access cancer specific RNA and prognostic data, click on the cancer name. The cancer types are color-coded according to which type of normal organ the cancer originates from. Read more RNA cancer category: Not detected

PROTEIN EXPRESSIONⁱ Antibody staining in 20 different cancers is summarized by a selection of four standard cancer tissue samples representative of the overall staining pattern. From left: colorectal cancer, breast cancer, prostate cancer and lung cancer. An additional fifth image can be added as a complement. The assay and annotation is described here. Note that samples used for immunohistochemistry by the Human Protein Atlas do not correspond to samples in the TCGA dataset. For histological reference, visit the histological dictionary.
Colorectal cancer Breast cancer Prostate cancer Lung cancer
PROTEIN EXPRESSION SUMMARYⁱ For each cancer, color-coded bars indicate the percentage of patients (maximum 12 patients) with high and medium protein expression level. The cancer types are color-coded according to which type of normal organ the cancer originates from. Low or not detected protein expression results in a white bar. Mouse-over function shows details about expression level and normal tissue of origin. The images and annotations can be accessed by clicking on the cancer name or protein expression bar. If more than one antibody is analyzed, the tabs at the top of the staining summary section can be used to toggle between the different antibodies. Read more
Organ Expression Alphabetical
HPA042585 HPA044022 HPA046691 HPA052337 HPA055498 Most cancer tissues showed moderate cytoplasmic and nuclear positivity. Hepatocellular carcinomas and occasional colorectal cancers displayed strong immunoreactivity. Many lymphomas and renal cell carcinomas were weakly stained or negative. Cancer tissues showed weak to moderate cytoplasmic positivity with additional nuclear staining in several cases. Occasional cases of gliomas and a single case each of colorectal, endometrial, renal, stomach and pancreatic cancers displayed strong positivity. Lymphomas were negative. A majority of cancer tissues showed weak to moderate cytoplasmic and/or nuclear positivity. Few cases of cholangiocarcinomas exhibited strong immunoreactivity. Lymphomas, carcinoid and testicular cancers were in general negative. Most cancer tissues showed weak to moderate cytoplasmic positivity with additional membranous or nuclear staining in few cases. Lymphomas along with several lung, cervical, urothelial and renal cancers were negative. A single case of duct carcinoma of breast showed moderate nuclear staining. Occasional cases of cervix cancers exhibited moderate to strong positivity. Few cases of endometrial cancers and occasional cases of ovarian cancers displayed moderate cytoplasmic and nuclear immunoreactivity. A single case of seminoma showed moderate cytoplasmic staining. Remaining cancer tissues were negative.