COLEC11 protein expression summary - The Human Protein Atlas

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COLEC11

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HUMAN PROTEIN ATLAS SUMMARYⁱ General description of the gene and the encoded protein(s) using information from HGNC and Ensembl, as well as predictions made by the Human Protein Atlas project.
Proteinⁱ Full gene name according to HGNC.	Collectin subfamily member 11
Gene nameⁱ Official gene symbol, which is typically a short form of the gene name, according to HGNC.	COLEC11 (CL-K1, MGC3279)
Tissue specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (gallbladder, liver)
Single cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Ito cells, Proximal tubular cells, Sertoli cells, Peritubular cells)
Blood specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed blood cell samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low immune cell specificity
Brain specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low human brain regional specificity
Cancer prognostic summary	Gene product is not prognostic
Predicted locationⁱ All transcripts of all genes have been analyzed regarding the location(s) of corresponding protein based on prediction methods for signal peptides and transmembrane regions. Genes with at least one transcript predicted to encode a secreted protein, according to prediction methods or to UniProt location data, have been further annotated and classified with the aim to determine if the corresponding protein(s) are secreted or actually retained in intracellular locations or membrane-attached. Remaining genes, with no transcript predicted to encode a secreted protein, will be assigned the prediction-based location(s). The annotated location overrules the predicted location, so that a gene encoding a predicted secreted protein that has been annotated as intracellular will have intracellular as the final location. Read more	Intracellular, Secreted (different isoforms)
Extracellular locationⁱ All genes with at least one isoform expected to be secreted to the extracellular environment have been annotated and classified either as secreted to blood or as locally secreted, depending on the predicted final location of the corresponding protein. Proteins expected to be locally secreted have been further classified according to their site of expression. Read more	Secreted to blood
Protein function (UniProt)ⁱ Useful information about the protein provided by UniProt.	Lectin that plays a role in innate immunity, apoptosis and embryogenesis 1, 2, 3. Calcium-dependent lectin that binds self and non-self glycoproteins presenting high mannose oligosaccharides with at least one terminal alpha-1,2-linked mannose epitope 4. Primarily recognizes the terminal disaccharide of the glycan 5. Also recognizes a subset of fucosylated glycans and lipopolysaccharides 6, 7. Plays a role in innate immunity through its ability to bind non-self sugars presented by microorganisms and to activate the complement through the recruitment of MAPS1 8, 9. Also plays a role in apoptosis through its ability to bind in a calcium-independent manner the DNA present at the surface of apoptotic cells and to activate the complement in response to this binding (Probable). Finally, plays a role in development, probably serving as a guidance cue during the migration of neural crest cells and other cell types during embryogenesis 10, 11.... show less
Molecular function (UniProt)ⁱ Keywords assigned by UniProt to proteins due to their particular molecular function.	Developmental protein
Biological process (UniProt)ⁱ Keywords assigned by UniProt to proteins because they are involved in a particular biological process.	Immunity, Innate immunity
Disease involvementⁱ Disease related keywords assigned by UniProt combined with Cancer-related genes and FDA approved drug targets Read more	Disease mutation
Ligand (UniProt)ⁱ Keywords assigned by UniProt to proteins because they bind, are associated with, or whose activity is dependent of some molecule.	Calcium, Lectin, Mannose-binding, Metal-binding
Gene summary (Entrez)ⁱ Useful information about the gene from Entrez	This gene encodes a member of the collectin family of C-type lectins that possess collagen-like sequences and carbohydrate recognition domains. Collectins are secreted proteins that play important roles in the innate immune system by binding to carbohydrate antigens on microorganisms, facilitating their recognition and removal. The encoded protein binds to multiple sugars with a preference for fucose and mannose. Mutations in this gene are a cause of 3MC syndrome-2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]... show less

TISSUE ATLASⁱ Summary of data presented in the Tissue Atlas and representative images of protein expression (left) and mRNA expression (right). The images are clickable and will redirect to more Tissue Atlas data. The Tissue Atlas contains information regarding the expression profiles of protein-coding genes in normal human tissue, both on the mRNA and protein level. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Tissue specificity (RNA)ⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: tissue enriched, group enriched, tissue enhanced, low tissue specificity and not detected. Read more	Tissue enhanced (gallbladder, liver)
Tissue distribution (RNA)ⁱ The RNA distribution category is based on mRNA expression levels in the analyzed samples based on a combination of data from HPA, GTEX and FANTOM5. The categories include: detected in all, detected in many, detected in some, detected in single and not detected. Read more	Detected in many
Protein expressionⁱ A summary of the overall protein expression pattern across the analyzed normal tissues. The summary is based on knowledge-based annotation. "Estimation of protein expression could not be performed. View primary data." is shown for genes analyzed with a knowledge-based approach where available RNA-seq and gene/protein characterization data has been evaluated as not sufficient in combination with immunohistochemistry data to yield a reliable estimation of the protein expression profile. Read more	Cytoplasmic expression in several tissues, including gallbladder and liver.

SINGLE CELL TYPE ATLASⁱ Summary of data presented in the Cell Type Atlas and an interactive image showing mRNA expression in cell type groups e.g. epithelial cells and germ cells. The image is clickable and will redirect to more Cell Type Atlas data. The Cell Type Atlas contains information about single cell type RNA expression based on scRNAseq of human tissues. The data also covers transcriptomics analysis of human blood and cultured cell lines. Read more

Cell type specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed cell types based on scRNA-seq data from normal tissues. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Group enriched (Ito cells, Proximal tubular cells, Sertoli cells, Peritubular cells)
Cell line specificityⁱ RNA specificity category based on RNA sequencing data from all cell lines in the Human Protein Atlas. Genes are classified into six different categories (enriched, group enriched, enhanced, low specificity and not detected) according to their RNA expression levels across the panel of cell lines.	Group enriched (HHSteC, SH-SY5Y)

PATHOLOGY ATLASⁱ Summary of data presented in the Pathology Atlas , with representative images of protein expression in cancer (left) and correlation between mRNA expression and patient survival (right). Images are clickable and redirect to pages with more Pathology Atlas data. The Pathology Atlas contains mRNA and protein expression data from 17 different forms of human cancer, as well as correlation analysis of mRNA expression and patient survival. The protein expression data is derived from antibody-based protein profiling using immunohistochemistry. Read more

Prognostic summary	Gene product is not prognostic
Cancer specificity (RNA)ⁱ Specificity of RNA expression in 17 cancer types is categorized as either cancer enriched, group enriched, cancer enhanced, low cancer specificity and not detected. Read more	Cancer enhanced (liver cancer)
Cancer distribution (RNA)ⁱ Distribution of RNA expression in 17 cancer types is categorized as either detected in single, detected in some, detected in many, detected in all, or not detected. Read more	Detected in many

BRAIN ATLASⁱ Summary of data presented in the Brain Atlas and a representative image of mRNA expression in the human brain. The image is clickable and will redirect to more Brain Atlas data. The Brain Atlas explores the protein expression in the mammalian brain by visualization and integration of data from three mammalian species (human, pig and mouse). Transcriptomics data combined with affinity-based protein in situ localization down to single cell level is available in a brain-centric sub atlas of the Human Protein Atlas. Read more

Human regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Pig regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Low region specificity
Mouse regional specificityⁱ The regional specificity category is based on mRNA expression levels in the analyzed brain samples, grouped into 10 main brain regions and calculated for the three different species. The human brain expression profile is based on a combination of data from GTEX and FANTOM5. The specificity categories include: regionally enriched, group enriched, regionally enhanced, low regional specificity and not detected. The classification rules are the same used for the tissue specificity category. Read more	Not detected

BLOOD ATLASⁱ Summary of data presented in the Blood Atlas and a representative image of mRNA expression in immune cells in the blood. The image is clickable and will redirect to more Blood Atlas data. The Blood Atlas contains single cell type RNA information covering various immune cells in the blood, e.g. B-cells and granulocytes. Analysis of the human secretome (including annotation of the genes predicted to be actively secreted to human blood) and proteins detected in human blood are also presented. Read more

Secretome annotationⁱ All genes with at least one predicted secreted isoform have been annotated and classified with the aim to determine if the corresponding protein(s) are: secreted into blood locally secreted or actually being attached to membrane or retained in intracellular locations like mitochondria, endoplasmatic reticulum (ER), Golgi apparatus or lysosomes. Read more	Secreted to blood
Immune cell specificityⁱ The RNA specificity category is based on mRNA expression levels in the analyzed samples based on data from HPA. The categories include: cell type enriched, group enriched, cell type enhanced, low cell type specificity and not detected. Read more	Low cell type specificity
Detected in blood by immunoassayⁱ The blood-based immunoassay category applies to actively secreted proteins and is based on plasma or serum protein concentrations established with enzyme-linked immunosorbent assays, compiled from a literature search. The categories include: detected and not detected, where detection refers to a concentration found in the literature search. Read more	No
Detected in blood by mass spectrometryⁱ Detection or not of the gene in blood, based on spectral count estimations from a publicly available mass spectrometry-based plasma proteomics data set obtained from the PeptideAtlas.	Yes

CELL ATLASⁱ Summary of data presented in the Cell Atlas and a representative image of subcellular localization. The Cell Atlas provides RNA expression data derived from RNA sequencing of a large panel of cell lines and protein localization data derived from antibody-based profiling by immunofluorescence confocal microscopy, using a subset of cell lines selected based on RNA expression. Read more

Main locationⁱ Main subcellular location(s) and reliability score(s) for the encoded protein(s) in human cells. The main location(s) may be characterized by presence in all tested cell lines and/or ihigher staining intensity compared to the potential additional location(s). If available, links to overrepresentation analyses in Reactome, a free, open-source, curated and peer reviewed biological pathway database, are provided. An analysis is done for the corresponding gene set of the proteome localizing to the main and additional locations of the protein on this page, respectively. Read more	Not available
Cell cycle dependencyⁱ Cell-cycle dependance of single-cell varations in RNA and/or protein expression as observed in an additional assay for characterizing single-cell varations. "NA" indicates a lack of such data. Read more	NA

GENE INFORMATIONⁱ Gene information from Ensembl and Entrez, as well as links to available gene identifiers are displayed here. Information was retrieved from Ensembl if not indicated otherwise.
Gene name	COLEC11 (HGNC Symbol)
Synonyms	CL-K1, MGC3279
Description	Collectin subfamily member 11 (HGNC Symbol)
Chromosome	2
Cytoband	p25.3
Chromosome location (bp)	3594832 - 3644644
Number of transcriptsⁱ Number of protein-coding transcripts from the gene as defined by Ensembl.	9
Protein evidence	Evidence at protein level (all genes)
Protein classⁱ Assigned HPA protein class(es) for the encoded protein(s). Read more	Disease related genes Plasma proteins
Ensembl	ENSG00000118004 (version 92.38)
Entrez gene	78989
UniProt	Q9BWP8 (UniProt - Evidence at protein level)
neXtProt	NX_Q9BWP8
Antibodypedia	COLEC11 antibodies

PROTEIN BROWSERⁱ

COLEC11-201

COLEC11-202

COLEC11-203

COLEC11-204

COLEC11-205

COLEC11-206

COLEC11-207

COLEC11-209

COLEC11-211

PROTEIN INFORMATIONⁱ The protein information section displays alternative protein-coding transcripts (splice variants) encoded by this gene according to the Ensembl database. The ENSP identifier links to the Ensembl website protein summary, while the ENST identifier links to the Ensembl website transcript summary for the selected splice variant. The data in the UniProt column can be expanded to show links to all matching UniProt identifiers for this protein. The protein classes assigned to this protein are shown if expanding the data in the protein class column. Parent protein classes are in bold font and subclasses are listed under the parent class. The Gene Ontology terms assigned to this protein are listed if expanding the Gene ontology column. The length of the protein (amino acid residues according to Ensembl), molecular mass (kDalton), predicted signal peptide (according to a majority of the signal peptide predictors SPOCTOPUS, SignalP 4.0, and Phobius) and the number of predicted transmembrane region(s) (according to MDM) are also reported.
Splice variant	UniProt	Protein class	Gene ontology	Length & mass	Signal peptide (predicted)	Transmembrane regions (predicted)
COLEC11-201 ENSP00000236693 ENST00000236693	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	268 aa 29 kDa	No	0
COLEC11-202 ENSP00000339168 ENST00000349077	Q9BWP8 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	271 aa 28.7 kDa	Yes	0
COLEC11-203 ENSP00000371494 ENST00000382062	Q9BWP8 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins SPOCTOPUS predicted secreted proteins Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	247 aa 26.3 kDa	Yes	0
COLEC11-204 ENSP00000384882 ENST00000402794	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	221 aa 23.9 kDa	No	0
COLEC11-205 ENSP00000385653 ENST00000402922	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	221 aa 23.9 kDa	No	0
COLEC11-206 ENSP00000385130 ENST00000403096	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	245 aa 26.2 kDa	No	0
COLEC11-207 ENSP00000385827 ENST00000404205	Q9BWP8 [Direct mapping] Collectin-11 Show all	Predicted intracellular proteins Intracellular proteins predicted by MDM and MDSEC Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	197 aa 21.6 kDa	No	0
COLEC11-209 ENSP00000411770 ENST00000418971	Q9BWP8 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Plasma proteins Disease related genes Mapped to neXtProt neXtProt - Evidence at protein level Protein evidence (Peptideatlas) Show all	GO:0001867 [complement activation, lectin pathway] GO:0004252 [serine-type endopeptidase activity] GO:0005537 [mannose binding] GO:0005576 [extracellular region] GO:0005581 [collagen trimer] GO:0006508 [proteolysis] GO:0006898 [receptor-mediated endocytosis] GO:0006956 [complement activation] GO:0007275 [multicellular organism development] GO:0030246 [carbohydrate binding] GO:0032502 [developmental process] Show all	285 aa 30.2 kDa	Yes	0
COLEC11-211 ENSP00000393167 ENST00000438814	C9JWT5 [Direct mapping] Collectin-11 Show all	MEMSAT3 predicted membrane proteins MEMSAT-SVM predicted membrane proteins SPOCTOPUS predicted membrane proteins THUMBUP predicted membrane proteins TMHMM predicted membrane proteins Predicted secreted proteins Secreted proteins predicted by MDSEC SignalP predicted secreted proteins Phobius predicted secreted proteins Show all		123 aa 12.2 kDa	Yes	0

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